Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4498731..4500375 Replicon chromosome
Accession NZ_CP090588
Organism Pectobacterium aroidearum strain AK042

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag L0Y25_RS20365 Protein ID WP_256553922.1
Coordinates 4498731..4500065 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag L0Y25_RS20370 Protein ID WP_256553923.1
Coordinates 4500070..4500375 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y25_RS20335 (L0Y25_20310) 4494812..4495690 + 879 WP_256553920.1 integrase domain-containing protein -
L0Y25_RS20340 (L0Y25_20315) 4495693..4495893 + 201 WP_014698606.1 AlpA family transcriptional regulator -
L0Y25_RS20345 (L0Y25_20320) 4495893..4496156 + 264 Protein_3981 ash family protein -
L0Y25_RS20350 (L0Y25_20325) 4496250..4496426 + 177 WP_226306425.1 hypothetical protein -
L0Y25_RS20355 (L0Y25_20330) 4496419..4497303 + 885 Protein_3983 toprim domain-containing protein -
L0Y25_RS20360 (L0Y25_20335) 4497367..4498455 + 1089 WP_256554949.1 helicase RepA family protein -
L0Y25_RS20365 (L0Y25_20340) 4498731..4500065 - 1335 WP_256553922.1 type II toxin-antitoxin system HipA family toxin Toxin
L0Y25_RS20370 (L0Y25_20345) 4500070..4500375 - 306 WP_256553923.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y25_RS20375 (L0Y25_20350) 4500682..4500843 - 162 WP_256553924.1 CopG family transcriptional regulator -
L0Y25_RS20380 (L0Y25_20355) 4500862..4502118 - 1257 WP_256553925.1 tyrosine-type recombinase/integrase -
L0Y25_RS20390 (L0Y25_20365) 4502652..4503728 - 1077 WP_180778926.1 LPS export ABC transporter permease LptG -
L0Y25_RS20395 (L0Y25_20370) 4503728..4504843 - 1116 WP_012773102.1 LPS export ABC transporter permease LptF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50726.82 Da        Isoelectric Point: 5.6849

>T231288 WP_256553922.1 NZ_CP090588:c4500065-4498731 [Pectobacterium aroidearum]
MPRIQQRLAIWMNGIQVGFWEKTRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQIWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVKYRPLCGAEIAAILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHEGQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEEQKALVVERF
DRRWSSDQQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIQRRHWVNHGELTGLGRRQVEAMMDDI
ISRTPEVIERVSSLLPESFPPELAECVFDGMRQQCGRLQELQRK

Download         Length: 1335 bp

>T231288 NZ_CP126323:3824334-3824861 [Salmonella enterica subsp. enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGCCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11327.13 Da        Isoelectric Point: 10.5325

>AT231288 WP_256553923.1 NZ_CP090588:c4500375-4500070 [Pectobacterium aroidearum]
MNTVYPLKTLNQLRPLLIGFRKAKGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTILGVEVVLSSGPRVHFSM
SSSTMEEPEKPIDSPARREKW

Download         Length: 306 bp

>AT231288 NZ_CP126323:3824047-3824337 [Salmonella enterica subsp. enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References