Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4118273..4118933 Replicon chromosome
Accession NZ_CP090588
Organism Pectobacterium aroidearum strain AK042

Toxin (Protein)


Gene name cptA Uniprot ID A0A7W2E4X8
Locus tag L0Y25_RS18595 Protein ID WP_012773341.1
Coordinates 4118273..4118686 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C6D8Y5
Locus tag L0Y25_RS18600 Protein ID WP_012773340.1
Coordinates 4118667..4118933 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y25_RS18570 (L0Y25_18545) 4113650..4114549 - 900 WP_012773347.1 site-specific tyrosine recombinase XerD -
L0Y25_RS18575 (L0Y25_18550) 4114861..4116189 + 1329 WP_181845156.1 MFS transporter -
L0Y25_RS18580 (L0Y25_18555) 4116352..4116870 + 519 WP_012773344.1 flavodoxin FldB -
L0Y25_RS18585 (L0Y25_18560) 4116899..4117222 + 324 WP_180777498.1 hypothetical protein -
L0Y25_RS18590 (L0Y25_18565) 4117268..4118203 - 936 WP_256553822.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
L0Y25_RS18595 (L0Y25_18570) 4118273..4118686 - 414 WP_012773341.1 protein YgfX Toxin
L0Y25_RS18600 (L0Y25_18575) 4118667..4118933 - 267 WP_012773340.1 FAD assembly factor SdhE Antitoxin
L0Y25_RS18605 (L0Y25_18580) 4119169..4120170 + 1002 WP_256553823.1 tRNA-modifying protein YgfZ -
L0Y25_RS18610 (L0Y25_18585) 4120225..4120872 - 648 WP_012773338.1 hemolysin III family protein -
L0Y25_RS18615 (L0Y25_18590) 4121285..4121893 + 609 WP_181829659.1 HD domain-containing protein -
L0Y25_RS18620 (L0Y25_18595) 4121937..4122941 + 1005 WP_181847023.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16302.21 Da        Isoelectric Point: 10.6525

>T231285 WP_012773341.1 NZ_CP090588:c4118686-4118273 [Pectobacterium aroidearum]
VAQWQCDLRVSWRMQLLSLIVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDRQQLWLASDSMGDDEWRHLRQLLLQQKNWAR

Download         Length: 414 bp

>T231285 NZ_CP126323:c2644520-2644417 [Salmonella enterica subsp. enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10465.94 Da        Isoelectric Point: 6.2223

>AT231285 WP_012773340.1 NZ_CP090588:c4118933-4118667 [Pectobacterium aroidearum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLSDSDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT231285 NZ_CP126323:2644415-2644560 [Salmonella enterica subsp. enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E4X8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E501

References