Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3914839..3915365 Replicon chromosome
Accession NZ_CP090588
Organism Pectobacterium aroidearum strain AK042

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag L0Y25_RS17750 Protein ID WP_256553763.1
Coordinates 3915060..3915365 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID E0SK21
Locus tag L0Y25_RS17745 Protein ID WP_012773205.1
Coordinates 3914839..3915057 (+) Length 73 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y25_RS17725 (L0Y25_17700) 3910972..3911166 - 195 WP_012773549.1 YlcI/YnfO family protein -
L0Y25_RS17730 (L0Y25_17705) 3911352..3911693 + 342 WP_256553761.1 hypothetical protein -
L0Y25_RS17735 (L0Y25_17710) 3911822..3913132 + 1311 WP_180776519.1 IS4 family transposase -
L0Y25_RS17740 (L0Y25_17715) 3914037..3914780 + 744 WP_256553762.1 MobC family replication-relaxation protein -
L0Y25_RS17745 (L0Y25_17720) 3914839..3915057 + 219 WP_012773205.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
L0Y25_RS17750 (L0Y25_17725) 3915060..3915365 + 306 WP_256553763.1 type II toxin-antitoxin system toxin CcdB Toxin
L0Y25_RS17755 (L0Y25_17730) 3916065..3918521 + 2457 WP_112092901.1 N-6 DNA methylase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3909429..3925622 16193
- flank IS/Tn - - 3911822..3913132 1310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-100)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 11785.63 Da        Isoelectric Point: 4.8564

>T231284 WP_256553763.1 NZ_CP090588:3915060-3915365 [Pectobacterium aroidearum]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIETHHLSEKVNKTLFPQIHIEGEDYRLMTTELSSVPVEVIGEAI
VDLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T231284 NZ_CP126323:807210-807497 [Salmonella enterica subsp. enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8201.16 Da        Isoelectric Point: 7.2038

>AT231284 WP_012773205.1 NZ_CP090588:3914839-3915057 [Pectobacterium aroidearum]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQHGSFADENRNW

Download         Length: 219 bp

>AT231284 NZ_CP126323:807484-807786 [Salmonella enterica subsp. enterica]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB E0SK21

References