Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3683902..3684527 Replicon chromosome
Accession NZ_CP090588
Organism Pectobacterium aroidearum strain AK042

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag L0Y25_RS16770 Protein ID WP_005976087.1
Coordinates 3684324..3684527 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag L0Y25_RS16765 Protein ID WP_005976089.1
Coordinates 3683902..3684270 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y25_RS16750 (L0Y25_16730) 3679533..3682661 + 3129 WP_015839362.1 efflux RND transporter permease subunit -
L0Y25_RS16755 (L0Y25_16735) 3682896..3683144 + 249 WP_015839361.1 type B 50S ribosomal protein L31 -
L0Y25_RS16760 (L0Y25_16740) 3683162..3683305 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
L0Y25_RS16765 (L0Y25_16745) 3683902..3684270 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
L0Y25_RS16770 (L0Y25_16750) 3684324..3684527 + 204 WP_005976087.1 HHA domain-containing protein Toxin
L0Y25_RS16780 (L0Y25_16760) 3685272..3685592 + 321 WP_015839360.1 MGMT family protein -
L0Y25_RS16785 (L0Y25_16765) 3685612..3686193 - 582 WP_181848112.1 YbaY family lipoprotein -
L0Y25_RS16790 (L0Y25_16770) 3686406..3687269 + 864 WP_181848113.1 acyl-CoA thioesterase II -
L0Y25_RS16795 (L0Y25_16775) 3687422..3688708 - 1287 WP_015839357.1 ammonium transporter AmtB -
L0Y25_RS16800 (L0Y25_16780) 3688746..3689084 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T231283 WP_005976087.1 NZ_CP090588:3684324-3684527 [Pectobacterium aroidearum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T231283 NZ_CP126323:761736-762044 [Salmonella enterica subsp. enterica]
ATGCAATACATGGTTTATCACAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT231283 WP_005976089.1 NZ_CP090588:3683902-3684270 [Pectobacterium aroidearum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT231283 NZ_CP126323:761494-761733 [Salmonella enterica subsp. enterica]
ATGCCAGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCATGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References