Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3200016..3200569 Replicon chromosome
Accession NZ_CP090588
Organism Pectobacterium aroidearum strain AK042

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag L0Y25_RS14675 Protein ID WP_039508990.1
Coordinates 3200016..3200330 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag L0Y25_RS14680 Protein ID WP_039551174.1
Coordinates 3200333..3200569 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y25_RS14630 (L0Y25_14615) 3195064..3195288 + 225 WP_015840869.1 DUF2594 family protein -
L0Y25_RS14635 (L0Y25_14620) 3195381..3195668 - 288 WP_015840870.1 hypothetical protein -
L0Y25_RS14645 (L0Y25_14630) 3196572..3197984 + 1413 WP_181847877.1 D-serine/D-alanine/glycine transporter -
L0Y25_RS14650 (L0Y25_14635) 3198156..3198422 - 267 WP_015840872.1 anti-adapter protein IraP -
L0Y25_RS14655 (L0Y25_14640) 3198818..3199087 - 270 Protein_2871 LysR family transcriptional regulator -
L0Y25_RS14665 (L0Y25_14650) 3199717..3199881 + 165 Protein_2872 Arm DNA-binding domain-containing protein -
L0Y25_RS14670 (L0Y25_14655) 3199881..3199982 + 102 Protein_2873 mobilization protein mobC -
L0Y25_RS14675 (L0Y25_14660) 3200016..3200330 - 315 WP_039508990.1 CcdB family protein Toxin
L0Y25_RS14680 (L0Y25_14665) 3200333..3200569 - 237 WP_039551174.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
L0Y25_RS14685 (L0Y25_14670) 3200897..3201841 - 945 WP_256553541.1 zincin-like metallopeptidase domain-containing protein -
L0Y25_RS14690 (L0Y25_14675) 3202311..3204266 + 1956 WP_256553542.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3177343..3212440 35097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11521.45 Da        Isoelectric Point: 7.9859

>T231282 WP_039508990.1 NZ_CP090588:c3200330-3200016 [Pectobacterium aroidearum]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRSQVKAAIDFLIDGF

Download         Length: 315 bp

>T231282 NZ_CP126323:721561-721845 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCCTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8976.05 Da        Isoelectric Point: 6.4610

>AT231282 WP_039551174.1 NZ_CP090588:c3200569-3200333 [Pectobacterium aroidearum]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRYHEAKKWQEENKEALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp

>AT231282 NZ_CP126323:721329-721571 [Salmonella enterica subsp. enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References