Detailed information of TA system TA231279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 244487..245104
• Replicon: chromosome
• Accession: NZ_CP090588
• Organism: Pectobacterium aroidearum strain AK042

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C6DHN3
• Locus tag: L0Y25_RS01125
• Protein ID: WP_010281507.1
• Coordinates: 244925..245104 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: L0Y25_RS01120
• Protein ID: WP_180779155.1
• Coordinates: 244487..244897 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y25_RS01105 (L0Y25_01105)	240311..241354	-	1044	WP_256554160.1	DNA-binding transcriptional regulator CytR	-
L0Y25_RS01110 (L0Y25_01110)	241631..243829	-	2199	WP_256554161.1	primosomal protein N'	-
L0Y25_RS01115 (L0Y25_01115)	244145..244360	+	216	WP_012772907.1	50S ribosomal protein L31	-
L0Y25_RS01120 (L0Y25_01120)	244487..244897	-	411	WP_180779155.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L0Y25_RS01125 (L0Y25_01125)	244925..245104	-	180	WP_010281507.1	type II toxin-antitoxin system HicA family toxin	Toxin
L0Y25_RS01130 (L0Y25_01130)	245202..246212	-	1011	WP_012772909.1	iron ABC transporter permease	-
L0Y25_RS01135 (L0Y25_01135)	246209..247171	-	963	WP_181847424.1	ABC transporter substrate-binding protein	-
L0Y25_RS01140 (L0Y25_01140)	247181..247978	-	798	WP_256554162.1	ABC transporter ATP-binding protein	-
L0Y25_RS01145 (L0Y25_01145)	248195..248512	-	318	WP_005973355.1	met regulon transcriptional regulator MetJ	-
L0Y25_RS01150 (L0Y25_01150)	248700..249860	+	1161	WP_012772912.1	cystathionine gamma-synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6560.69 Da
• Isoelectric Point: 10.7838

>T231279 WP_010281507.1 NZ_CP090588:c245104-244925 [Pectobacterium aroidearum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Nucleotide

• Length: 180 bp

>T231279 NZ_CP126323:306351-306719 [Salmonella enterica subsp. enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14492.36 Da
• Isoelectric Point: 4.3391

>AT231279 WP_180779155.1 NZ_CP090588:c244897-244487 [Pectobacterium aroidearum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLVEMGQDIPTVSTVGQLAKGSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Nucleotide

• Length: 411 bp

>AT231279 NZ_CP126323:306133-306354 [Salmonella enterica subsp. enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A7W2I1S0