Detailed information of TA system TA231278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 207775..208409
• Replicon: chromosome
• Accession: NZ_CP090588
• Organism: Pectobacterium aroidearum strain AK042

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: L0Y25_RS00955
• Protein ID: WP_181845733.1
• Coordinates: 207775..208050 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: L0Y25_RS00960
• Protein ID: WP_181830203.1
• Coordinates: 208047..208409 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y25_RS00925 (L0Y25_00925)	203046..203561	-	516	WP_256554145.1	phage major tail tube protein	-
L0Y25_RS00930 (L0Y25_00930)	203562..204746	-	1185	WP_256554146.1	phage tail sheath family protein	-
L0Y25_RS00935 (L0Y25_00935)	204894..206036	+	1143	WP_256554147.1	phage late control D family protein	-
L0Y25_RS00940 (L0Y25_00940)	206073..206321	+	249	WP_256554148.1	ogr/Delta-like zinc finger family protein	-
L0Y25_RS00945 (L0Y25_00945)	206441..206773	+	333	WP_256554149.1	zinc ribbon domain-containing protein	-
L0Y25_RS00950 (L0Y25_00950)	206778..207521	+	744	WP_256554150.1	type VI secretion system-associated protein TagO	-
L0Y25_RS00955 (L0Y25_00955)	207775..208050	+	276	WP_181845733.1	type II toxin-antitoxin system HicA family toxin	Toxin
L0Y25_RS00960 (L0Y25_00960)	208047..208409	+	363	WP_181830203.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L0Y25_RS00965 (L0Y25_00965)	208784..209971	+	1188	WP_256554151.1	sugar transporter	-
L0Y25_RS00970 (L0Y25_00970)	210015..210917	+	903	WP_012772881.1	CDF family cation-efflux transporter FieF	-
L0Y25_RS00975 (L0Y25_00975)	211125..212087	+	963	WP_012772882.1	6-phosphofructokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-80)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10051.64 Da
• Isoelectric Point: 11.1875

>T231278 WP_181845733.1 NZ_CP090588:207775-208050 [Pectobacterium aroidearum]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNVESLITALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVNL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T231278 NZ_CP126323:196293-196778 [Salmonella enterica subsp. enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCCGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13577.41 Da
• Isoelectric Point: 4.4981

>AT231278 WP_181830203.1 NZ_CP090588:208047-208409 [Pectobacterium aroidearum]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRNEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLNERMKQA

Nucleotide

• Length: 363 bp

>AT231278 NZ_CP126323:196018-196305 [Salmonella enterica subsp. enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA