Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4498565..4500209 Replicon chromosome
Accession NZ_CP090587
Organism Pectobacterium aroidearum strain AK049

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag L0Y26_RS20365 Protein ID WP_256553922.1
Coordinates 4498565..4499899 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag L0Y26_RS20370 Protein ID WP_256553923.1
Coordinates 4499904..4500209 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y26_RS20335 (L0Y26_20305) 4494646..4495524 + 879 WP_256553920.1 integrase domain-containing protein -
L0Y26_RS20340 (L0Y26_20310) 4495527..4495727 + 201 WP_014698606.1 AlpA family transcriptional regulator -
L0Y26_RS20345 (L0Y26_20315) 4495727..4495990 + 264 Protein_3981 ash family protein -
L0Y26_RS20350 (L0Y26_20320) 4496084..4496260 + 177 WP_226306425.1 hypothetical protein -
L0Y26_RS20355 (L0Y26_20325) 4496253..4497089 + 837 Protein_3983 toprim domain-containing protein -
L0Y26_RS20360 (L0Y26_20330) 4497201..4498289 + 1089 WP_256554949.1 helicase RepA family protein -
L0Y26_RS20365 (L0Y26_20335) 4498565..4499899 - 1335 WP_256553922.1 type II toxin-antitoxin system HipA family toxin Toxin
L0Y26_RS20370 (L0Y26_20340) 4499904..4500209 - 306 WP_256553923.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y26_RS20375 (L0Y26_20345) 4500516..4500677 - 162 WP_256553924.1 CopG family transcriptional regulator -
L0Y26_RS20380 (L0Y26_20350) 4500696..4501952 - 1257 WP_256553925.1 tyrosine-type recombinase/integrase -
L0Y26_RS20390 (L0Y26_20360) 4502486..4503562 - 1077 WP_180778926.1 LPS export ABC transporter permease LptG -
L0Y26_RS20395 (L0Y26_20365) 4503562..4504677 - 1116 WP_012773102.1 LPS export ABC transporter permease LptF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4490704..4501952 11248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50726.82 Da        Isoelectric Point: 5.6849

>T231274 WP_256553922.1 NZ_CP090587:c4499899-4498565 [Pectobacterium aroidearum]
MPRIQQRLAIWMNGIQVGFWEKTRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQIWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVKYRPLCGAEIAAILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHEGQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEEQKALVVERF
DRRWSSDQQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIQRRHWVNHGELTGLGRRQVEAMMDDI
ISRTPEVIERVSSLLPESFPPELAECVFDGMRQQCGRLQELQRK

Download         Length: 1335 bp

>T231274 NZ_CP126307:c4579910-4579620 [Bosea vestrisii]
ATACCTGAGCTTCGTCAGACGGCGGTCTTCTCGACATGGCTCGAGGACCTCCGCGACAACGCGGCCAAGGCACGCATCCT
CGTTCGGCTACGCCGGCTCGAACTCGGCAATCCCGGCGACGTCAAGCCGGTCGGCGAAGGCATGAGCGAAATGCGGGTCG
ATTACGGGCCCGGCTACCGGGTCTACTTCGTCCAGCGCGGCAAAGAGCTGATCATTCTTCTCTGTGGCGGCGATAAGCGA
ACGCAGGCGAACGACATAGCCCGAGCCAAGCAGATGGCGGCGGAGTATTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11327.13 Da        Isoelectric Point: 10.5325

>AT231274 WP_256553923.1 NZ_CP090587:c4500209-4499904 [Pectobacterium aroidearum]
MNTVYPLKTLNQLRPLLIGFRKAKGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTILGVEVVLSSGPRVHFSM
SSSTMEEPEKPIDSPARREKW

Download         Length: 306 bp

>AT231274 NZ_CP126307:c4579618-4579334 [Bosea vestrisii]
ATGGCAGACGAGACTCGCCCCTTCGACATCCAGAACCATCTCGCGACACAAGATGAGCAGGTCGCTTATCTGGAAGCCGC
CCTTGAAGATGGCGACCCCGCTTTCATCGCGGTCGCGCTCGGCGACATCGCACGGGCACGCGGTGTCACCACATTTGCCG
AAGAATCCGGTATCAGCCGCGAGACGATCTACAAGGCCTTCCGCGCCGGCGGTAATCCGACGCTGGAAACCTTGTCCAAG
GCGACGCGCGCCCTCGGCATGAAGCTGACGCTGGTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References