Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3683736..3684361 Replicon chromosome
Accession NZ_CP090587
Organism Pectobacterium aroidearum strain AK049

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag L0Y26_RS16770 Protein ID WP_005976087.1
Coordinates 3684158..3684361 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag L0Y26_RS16765 Protein ID WP_005976089.1
Coordinates 3683736..3684104 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y26_RS16750 (L0Y26_16725) 3679367..3682495 + 3129 WP_015839362.1 efflux RND transporter permease subunit -
L0Y26_RS16755 (L0Y26_16730) 3682730..3682978 + 249 WP_015839361.1 type B 50S ribosomal protein L31 -
L0Y26_RS16760 (L0Y26_16735) 3682996..3683139 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
L0Y26_RS16765 (L0Y26_16740) 3683736..3684104 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
L0Y26_RS16770 (L0Y26_16745) 3684158..3684361 + 204 WP_005976087.1 HHA domain-containing protein Toxin
L0Y26_RS16780 (L0Y26_16755) 3685106..3685426 + 321 WP_015839360.1 MGMT family protein -
L0Y26_RS16785 (L0Y26_16760) 3685446..3686027 - 582 WP_181848112.1 YbaY family lipoprotein -
L0Y26_RS16790 (L0Y26_16765) 3686240..3687103 + 864 WP_181848113.1 acyl-CoA thioesterase II -
L0Y26_RS16795 (L0Y26_16770) 3687256..3688542 - 1287 WP_015839357.1 ammonium transporter AmtB -
L0Y26_RS16800 (L0Y26_16775) 3688580..3688918 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T231269 WP_005976087.1 NZ_CP090587:3684158-3684361 [Pectobacterium aroidearum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T231269 NZ_CP126307:735630-736031 [Bosea vestrisii]
TTGACGCGCTACCTGCTCGACACCAACATCATTTCCGATCTGGTCCGGCAGCCACAGGGACGCGTCGCGAAACAGATCGC
GGAGGTCGGTGACCGCCAGGTCCTGACGAGCGCGATCGTCGCAGCCGAGTTGCGCTATGGCTGCCGGAAAGCCGGCTCGG
CGCGCCTGTCGGCGACCATCGAGGCCCTGCTCTTCGAGATCGAGACCATTCCTTTCGACGAAGCAGCCTCTCGCGCTTAC
GCTGATCTGCGTACGGCCCTCGAAGCCAAGGGCCAGCCCATCGGCGGCAACGACATGCTCATCGCCGCGCAGGCTCTGGC
GCTCGGCTGCGTCATGGTCACAGCTAACGTAAACGAGTTCGCACGCGTCGACGGGCTCGCGATAGAGAACTGGCTGGGTT
GA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT231269 WP_005976089.1 NZ_CP090587:3683736-3684104 [Pectobacterium aroidearum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT231269 NZ_CP126307:735397-735633 [Bosea vestrisii]
ATGAACGAGATCCGGCATGTCAGGCTGTTCCGCAACGGCCGCAATCAGGCGGTTCGCATTCCTGTGGAGTTCGAGCTTCC
CGGCGACGAGGCGCTGATGCGCCGCGACGGCGACCGCCTCGTCATCGAGCCGCTCGCGAAGCGGGGATTGACCGCCCTGC
TCGCCGGGCTGGAACCGCTCGACGAGGCTTTCCCGGAGATCGCCGATCCTCCGCCGGCACCGGAGCGCGGCCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References