Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 207775..208409 Replicon chromosome
Accession NZ_CP090587
Organism Pectobacterium aroidearum strain AK049

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L0Y26_RS00955 Protein ID WP_181845733.1
Coordinates 207775..208050 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L0Y26_RS00960 Protein ID WP_181830203.1
Coordinates 208047..208409 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y26_RS00925 (L0Y26_00925) 203046..203561 - 516 WP_256554145.1 phage major tail tube protein -
L0Y26_RS00930 (L0Y26_00930) 203562..204746 - 1185 WP_256554146.1 phage tail sheath family protein -
L0Y26_RS00935 (L0Y26_00935) 204894..206036 + 1143 WP_256554147.1 phage late control D family protein -
L0Y26_RS00940 (L0Y26_00940) 206073..206321 + 249 WP_256554148.1 ogr/Delta-like zinc finger family protein -
L0Y26_RS00945 (L0Y26_00945) 206441..206773 + 333 WP_256554149.1 zinc ribbon domain-containing protein -
L0Y26_RS00950 (L0Y26_00950) 206778..207521 + 744 WP_256554150.1 type VI secretion system-associated protein TagO -
L0Y26_RS00955 (L0Y26_00955) 207775..208050 + 276 WP_181845733.1 type II toxin-antitoxin system HicA family toxin Toxin
L0Y26_RS00960 (L0Y26_00960) 208047..208409 + 363 WP_181830203.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L0Y26_RS00965 (L0Y26_00965) 208784..209971 + 1188 WP_256554151.1 sugar transporter -
L0Y26_RS00970 (L0Y26_00970) 210015..210917 + 903 WP_012772881.1 CDF family cation-efflux transporter FieF -
L0Y26_RS00975 (L0Y26_00975) 211125..212087 + 963 WP_012772882.1 6-phosphofructokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10051.64 Da        Isoelectric Point: 11.1875

>T231264 WP_181845733.1 NZ_CP090587:207775-208050 [Pectobacterium aroidearum]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNVESLITALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVNL
REWLESIGVKP

Download         Length: 276 bp

>T231264 NZ_CP126273:c85531-85280 [Curtobacterium sp. MCBD17_040]
ATGCGCATCCTCAGCTACTCGGAGACGCGTTCCCACTTCGCCGAGACCCTCAACGCCGTCACGGACGACCGCGAGGAGGT
CGTGGTCACGCGCGCGGGCCACGAATCGGTCGTGCTCGTGTCCCTCGACGACTACGAGTCCCTGAAGGAGACCGCCTACC
TGCTGAGGAACCCCGCGAACGCCCGGCGGCTGCTCGCCTCGATCGAGCGCCTGGAGCGCGGGGAGGGCACGGAGCGGGAC
CTGGACGAGTGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13577.41 Da        Isoelectric Point: 4.4981

>AT231264 WP_181830203.1 NZ_CP090587:208047-208409 [Pectobacterium aroidearum]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRNEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLNERMKQA

Download         Length: 363 bp

>AT231264 NZ_CP126273:c85283-85023 [Curtobacterium sp. MCBD17_040]
GTGAGGTACGTCTGGGACGACGCTGCCTGGGCCGACTCCGAGTGGTGGCAACAGCAGGACCGGAAGATCGTCAAGCGGAT
CAACGGGTTGCTCCGTGACATCGCGCGCAACGGCAACGAGGGCATCGGCAAACCGGAGCCGCTCAAGCACGGGTTCCGTG
GGTACTGGTCCCGGCGCATCACGGACGAGCACCGTCTCGTGTACCGCGTCACGGACGACAGCGTCCTCATCGCGCAGTGC
CGGTACCACCACGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References