Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 39831..40383 Replicon plasmid pNYY1_3
Accession NZ_CP090582
Organism Methylobacterium radiotolerans strain NYY1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LZ599_RS31620 Protein ID WP_234742457.1
Coordinates 40093..40383 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LZ599_RS31615 Protein ID WP_029360219.1
Coordinates 39831..40100 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ599_RS31585 (LZ599_31585) 34879..35034 - 156 WP_234742453.1 hypothetical protein -
LZ599_RS31590 (LZ599_31590) 35256..35867 - 612 WP_234742492.1 recombinase family protein -
LZ599_RS31595 (LZ599_31595) 36022..37464 - 1443 WP_234742454.1 restriction endonuclease -
LZ599_RS31600 (LZ599_31600) 37703..38236 + 534 WP_234742455.1 hypothetical protein -
LZ599_RS31605 (LZ599_31605) 38553..38900 - 348 WP_234742456.1 hypothetical protein -
LZ599_RS31610 (LZ599_31610) 38900..39550 - 651 WP_029360218.1 ParA family protein -
LZ599_RS31615 (LZ599_31615) 39831..40100 + 270 WP_029360219.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LZ599_RS31620 (LZ599_31620) 40093..40383 + 291 WP_234742457.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ599_RS31625 (LZ599_31625) 40877..41692 + 816 WP_234742458.1 helix-turn-helix domain-containing protein -
LZ599_RS31630 (LZ599_31630) 41867..42088 + 222 WP_234742459.1 hypothetical protein -
LZ599_RS31635 (LZ599_31635) 42387..42620 + 234 WP_234742460.1 hypothetical protein -
LZ599_RS31640 (LZ599_31640) 42653..43165 - 513 WP_234742461.1 ProQ/FINO family protein -
LZ599_RS31645 (LZ599_31645) 43464..43898 + 435 WP_234742462.1 MucR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48959 48959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Antitoxin ParD

(3-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10545.06 Da        Isoelectric Point: 7.5692

>T231262 WP_234742457.1 NZ_CP090582:40093-40383 [Methylobacterium radiotolerans]
MSDYTLTRKAEADLFDIAVHGYRQFGVHQAEAYAAGLEQAFQLLADNPGMGRKADGIRPGVHRHEHASHVILYEVVTGGV
LILAIIHGRSVRRLAL

Download         Length: 291 bp

>T231262 NZ_CP126226:c1221616-1220870 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10266.63 Da        Isoelectric Point: 8.6044

>AT231262 WP_029360219.1 NZ_CP090582:39831-40100 [Methylobacterium radiotolerans]
MATMTISLPDPMKEWIEAQIRQGDYASTSDYVRDLVRRDRERRAHPELTLEDLRRIVDDARASGPSRRKVPEILARAKKH
AQAAQPLDE

Download         Length: 270 bp

>AT231262 NZ_CP126226:c1220869-1220699 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References