Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 313659..314329 Replicon plasmid pNYY1_1
Accession NZ_CP090580
Organism Methylobacterium radiotolerans strain NYY1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZ599_RS29380 Protein ID WP_053622647.1
Coordinates 313659..314093 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZ599_RS29385 Protein ID WP_053622648.1
Coordinates 314090..314329 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ599_RS29360 (LZ599_29360) 308852..309247 - 396 WP_053622644.1 hypothetical protein -
LZ599_RS29365 (LZ599_29365) 309665..310333 - 669 WP_053622645.1 glutathione S-transferase family protein -
LZ599_RS29370 (LZ599_29370) 310469..311362 + 894 WP_053622646.1 LysR family transcriptional regulator -
LZ599_RS29375 (LZ599_29375) 311781..312716 - 936 WP_024827520.1 site-specific integrase -
LZ599_RS29380 (LZ599_29380) 313659..314093 - 435 WP_053622647.1 type II toxin-antitoxin system VapC family toxin Toxin
LZ599_RS29385 (LZ599_29385) 314090..314329 - 240 WP_053622648.1 hypothetical protein Antitoxin
LZ599_RS29390 (LZ599_29390) 314762..315904 + 1143 Protein_269 IS3 family transposase -
LZ599_RS29395 (LZ599_29395) 316167..318080 + 1914 WP_053622649.1 potassium transporter Kup -
LZ599_RS29400 (LZ599_29400) 318377..319120 + 744 WP_234742361.1 TerC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..657971 657971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15914.20 Da        Isoelectric Point: 7.1369

>T231260 WP_053622647.1 NZ_CP090580:c314093-313659 [Methylobacterium radiotolerans]
MSERFLLDTNIISEIVKQGRDSVVLGVIAQVGEDSICTSAIVASELRFGVERKRSQALREKVERVLRNIEVLPYNSGCSQ
SYGIIRAALEREGRGIGPNDLLIAAQAHSLGMTLVTDNVHEFERVAGLRVVNWLDPSYSFRAAK

Download         Length: 435 bp

>T231260 NZ_CP126169:3722324-3722527 [Rahnella bonaserana]
ATGAACAAAATCGACTATTTGATGCGTTTAAGAAAATGCACCACTATTGATACACTTGAACGTGTCATTGAAAAGAATAA
GTACGAACTTTCCGACGACGAGCTGGAATTGTTTTACTCGGCGGCTGATCATCGTTTAGCGGAGCTAACGATGAACAAGC
TGTACGATAAAATCCCGGTATCAGTTTGGAAATTTGTACGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8754.05 Da        Isoelectric Point: 4.4012

>AT231260 WP_053622648.1 NZ_CP090580:c314329-314090 [Methylobacterium radiotolerans]
MDGKTASLFRNGRNQALRIPREYELPGTSARIRRLPNGNLEIEPVAETGLLAAFKDELPLPPQDCMDPVLELPIEAVDL

Download         Length: 240 bp

>AT231260 NZ_CP126169:3721910-3722278 [Rahnella bonaserana]
ATGGATGAGTACTCGCCTAAGCGGCATGATATCGCTCAGTTACGCTACCTGAATGAAATGTTGTATGATGAAGGCATCGC
GACACTGGGTGACAGTCACCACGGTTGGGTCAACGACCCTACTTCTGCTGTTAACCTGCAACTCAACGAACTGATTGAGC
ACATTGCATCCTTTGTGATGAGCTTTAAAATTAAGTATCCGGACGATACCCATTTAAGTGATCTGGTTGAAGAGTATCTG
GATGATACCTACACCCTGTTCAGCAATTATGGAATTAACGATTCTGATTTACGCCAATGGCAAAAGACCAAGAAGCGATT
ATTCAGAATGTTCTCAGGGGACTACATCTGTACCCTAATGAAGACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References