Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1923198..1923668 Replicon chromosome
Accession NZ_CP090575
Organism Staphylococcus epidermidis strain 11H

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KB225_RS09040 Protein ID WP_001829569.1
Coordinates 1923480..1923668 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KB225_RS09035 Protein ID WP_002438963.1
Coordinates 1923198..1923455 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB225_RS08995 (KB225_08995) 1918562..1919278 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KB225_RS09000 (KB225_09000) 1919439..1919861 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KB225_RS09005 (KB225_09005) 1920045..1920200 - 156 WP_001829648.1 hypothetical protein -
KB225_RS09010 (KB225_09010) 1920212..1920399 - 188 Protein_1743 hypothetical protein -
KB225_RS09015 (KB225_09015) 1920786..1921286 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KB225_RS09020 (KB225_09020) 1921557..1922144 - 588 WP_234773814.1 histidine phosphatase family protein -
KB225_RS09025 (KB225_09025) 1922358..1922594 + 237 WP_002457224.1 hypothetical protein -
KB225_RS09030 (KB225_09030) 1922586..1922789 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KB225_RS09035 (KB225_09035) 1923198..1923455 + 258 WP_002438963.1 hypothetical protein Antitoxin
KB225_RS09040 (KB225_09040) 1923480..1923668 + 189 WP_001829569.1 hypothetical protein Toxin
KB225_RS09045 (KB225_09045) 1923858..1924412 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KB225_RS09050 (KB225_09050) 1924472..1924705 - 234 WP_001829664.1 hypothetical protein -
KB225_RS09055 (KB225_09055) 1924989..1925735 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KB225_RS09060 (KB225_09060) 1925834..1926118 + 285 WP_001829635.1 hypothetical protein -
KB225_RS09065 (KB225_09065) 1926142..1926366 + 225 WP_001829613.1 hypothetical protein -
KB225_RS09070 (KB225_09070) 1926987..1927187 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1914170..1932764 18594
- flank IS/Tn - - 1920045..1920200 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T231259 WP_001829569.1 NZ_CP090575:1923480-1923668 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T231259 NZ_CP126169:c3246628-3246539 [Rahnella bonaserana]
GCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATCGTATTCG
GTCTTTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT231259 WP_002438963.1 NZ_CP090575:1923198-1923455 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT231259 NZ_CP126169:3246539-3246628 [Rahnella bonaserana]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TAATGCAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References