Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 792982..793511 Replicon chromosome
Accession NZ_CP090575
Organism Staphylococcus epidermidis strain 11H

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KB225_RS03645 Protein ID WP_001829891.1
Coordinates 793149..793511 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KB225_RS03640 Protein ID WP_001829931.1
Coordinates 792982..793152 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB225_RS03615 (KB225_03615) 788807..789286 + 480 WP_001829909.1 PH domain-containing protein -
KB225_RS03620 (KB225_03620) 789279..790784 + 1506 WP_001829976.1 PH domain-containing protein -
KB225_RS03625 (KB225_03625) 790771..791280 + 510 WP_001829888.1 PH domain-containing protein -
KB225_RS03630 (KB225_03630) 791328..791681 + 354 WP_001829915.1 holo-ACP synthase -
KB225_RS03635 (KB225_03635) 791747..792895 + 1149 WP_001829972.1 alanine racemase -
KB225_RS03640 (KB225_03640) 792982..793152 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KB225_RS03645 (KB225_03645) 793149..793511 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KB225_RS03650 (KB225_03650) 793856..794857 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KB225_RS03655 (KB225_03655) 794957..795283 + 327 WP_001829952.1 anti-sigma factor antagonist -
KB225_RS03660 (KB225_03660) 795285..795764 + 480 WP_001829903.1 anti-sigma B factor RsbW -
KB225_RS03665 (KB225_03665) 795739..796509 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T231257 WP_001829891.1 NZ_CP090575:793149-793511 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T231257 NZ_CP126169:2056175-2057470 [Rahnella bonaserana]
ATGGATAAGTTAACGCTCGCATTAAATGGCATTGCTGTCGGTACGCTTGAAAAAGGCGGCAGTGGTGAAATGTCATTTGT
TTACCATCAAAGCTGGCTCGATCGCCCCGGAGCCCGCGCTATATCATTATCATTACCTCTGCAGGCAGATAAATTCCGTG
GCGCGGTGGTGTACAATTTTTTCGATAATCTTCTGCCTGATAACGAACAAATACGCAGCCGCATACAGGCGCGTTTCCAG
ATCCCGACCAAACAACCCTTCGATTTGCTCTCGCGGATCGGCGGTGATTGCGTCGGTGCGATCCAGCTCTATCCTGAGGG
TGATCAGGTTGCGCCTGTCACTGAAATCCATGCCCGACCGCTTGACGAAAAAGATGTCGAACAGCTTTTGCAGGGGTATA
AGGATGCACCTTTGGGCATGGAAGCTGACATTGAAGACTTTCGAATTTCTCTGGCCGGTGCGCAGGAAAAAACAGCGCTG
CTCTGGTATCGCGACCAGTGGCACCGCCCGCAGGGAAGTACGCCTACCAGCCATATCCTTAAACTTCCTATTGGTTATAT
CGCTAACAATGGCATTGATCTCAGCGAGAGCGTGGAGAATGAATGGCTGTGCCTGAAGATAGCCGAAAAGTTTGGATTCC
CTGTTGCACGGTCTGAGATTGCCAGTTTTGGCGCTCAGAAGGTGTTGGTCGTTGAGCGTTTTGACCGCCGCTGGTCACAG
GATGGATCCTGGCTGATGCGTATACCTCAGGAAGATTTTTGTCAGGCGCTGGGTGTGGCTCCCGCATTGAAGTATGAATC
TGATGGCGGCCCCGGAATTGCACGTGCAATGAAGCTTTTACTGGGTTCTCAACGGGCGGGGGCGGACAGGGATATGTTCT
TCAAAAGCCAGATCCTCTTCTGGATGCTGGCCGCCATTGATGGTCATGCTAAAAATTTCAGTGTTTATATCGAGCCGGGC
AGCGCTTACCGCATGACGCCGCTGTATGACGTGATGTCAGCATTTCCTCTGATGAATCCACAAGGAATTCCGGCGAAGAA
AGCCAAAATGGCGATGGCTGTATTAGGGAAAAACCGGCATTTTCACTGGGACAGAATTCTTCCCCGCCATTTTGTGACGA
CGGCGCAACGGGTCGAGTACTCCAAAGAAAACGTTGCTGTGATGATGACGGAAATGAAGGAAAAAACTGAGCAGGTGATT
GCAGATGTTGAAGCAATAATACCTGCTAATTTTCCGGTAAAAATCAGTGATGCAATTTTTGCAGGCCTGCGCCATCAGGC
TGCACGTTTGCCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT231257 WP_001829931.1 NZ_CP090575:792982-793152 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT231257 NZ_CP126169:2055893-2056171 [Rahnella bonaserana]
CTGAGATTATCCGCCAGGGAGGATAATATGAACATTACATCTGCAAAAATGCTCGCCAATGCGCTGCGCAATGAGCGAAA
AAAGCGCAAACTCAGCCAAAGTAAAACGGCTGAAACCATTGGCCTGAAGCAGTCTACGGTTTCTGAGTTCGAAAATTATC
CGGACGGTACCCGTCTGGAAACACTGTTCAAATTATTGGCGGCGCTGGATTTAGAGCTACAGATCACGCCAAGAGATAGC
AATCCTAAGGAAAAGACGTCCTGGGATCAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References