Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 781799..782308 Replicon chromosome
Accession NZ_CP090575
Organism Staphylococcus epidermidis strain 11H

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KB225_RS03585 Protein ID WP_001829980.1
Coordinates 782099..782308 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KB225_RS03580 Protein ID WP_001829893.1
Coordinates 781799..782092 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB225_RS03555 (KB225_03555) 776807..777595 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KB225_RS03560 (KB225_03560) 777601..778239 + 639 WP_002505076.1 thiamine phosphate synthase -
KB225_RS03565 (KB225_03565) 778328..779200 + 873 WP_001832740.1 membrane protein insertase YidC -
KB225_RS03570 (KB225_03570) 779306..779959 - 654 WP_001829983.1 HD domain-containing protein -
KB225_RS03575 (KB225_03575) 780141..781625 - 1485 WP_001829964.1 cardiolipin synthase -
KB225_RS03580 (KB225_03580) 781799..782092 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KB225_RS03585 (KB225_03585) 782099..782308 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KB225_RS03590 (KB225_03590) 782451..782588 + 138 WP_001829949.1 Lmo0850 family protein -
KB225_RS03595 (KB225_03595) 782688..783899 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KB225_RS03600 (KB225_03600) 784290..785363 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KB225_RS03605 (KB225_03605) 785375..786730 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T231256 WP_001829980.1 NZ_CP090575:782099-782308 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T231256 NZ_CP126169:c1590611-1590153 [Rahnella bonaserana]
TTGAAGCTGTTTCGTATCGTTCAGACACGCCATCTGGCAACAGCCTGGTCGGGTGCCGGTGCGCAGCTTTATGGCGGGCG
CTGGAATCCGCCGGGCAGACCGGTAGTTTATGTCACCACCAGTATTTCGCTGGCGATCCTGGAAATCCTGGTGCATTTGC
AAAACAGCATGCTGATGCGGTCGTATACCTTACTGAGTATTGAAGTGCCGGAAGACCTGCTGGATACGCTGGAAGTTTCC
GAGCTGGCATCTGACTGGCGGAGTGCATCGCCGCCGGACAGCACACAACGTCAGGGTGACGAGTGGCTCGCGGAGGGTGA
TTATGTCGGGCTGAAAGTACCGTCGGTCATCGTGCCGTCGGAATACAACGTATTGCTGAATCCGCTGCATCCGGCTTTTG
TCGATTTACTGAGTTCAGTACAACGCGAGCCGATGATATTTGACCCGCGTCTGCAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT231256 WP_001829893.1 NZ_CP090575:781799-782092 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT231256 NZ_CP126169:c1591069-1590608 [Rahnella bonaserana]
ATGAATTCTAAAATTTCCGGGCTGTCTTCCAGCCTTTTGCAAGAACCTGCAACACCGCTTTGGCAGTCTGCGGGACTTCC
CGCAAGCAGCGGAATAAGTTTGATTAATGCCATACAAAAGGGATTTCCGGTTGATAGTATCAGCCGTCTTAATACTGAGC
TGGGATGGCCGAAAATGGTGTTACTGGAAATAATGGGGATTAACGAACGCAATTATGCGCGTCGTAAAGCCGGGAACGGA
TTGCTGAAAAGTGAAGAGAGCGAACGTGTCGCGCGGTTGGTACGCATCGTAGATGCCGCCACCGATTTGTTTGAAGGGGA
TCGTGTCTCTGCGCTCGAGTGGTTCACCCGCCCTGCTCCGGCGCTGGATGGCTCACGTCCGCTGGAACTGCTGTCCTCTG
AAGCGGGCGCGGTGGAAGTCAGCCGTCTGATCGGTCGTCTTGAGCACGGTGTTTTCAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References