Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4279465..4280263 Replicon chromosome
Accession NZ_CP090570
Organism Escherichia coli strain BY63

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag LZE53_RS21015 Protein ID WP_000854735.1
Coordinates 4279886..4280263 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag LZE53_RS21010 Protein ID WP_001285415.1
Coordinates 4279465..4279839 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZE53_RS20975 (4275396) 4275396..4276076 + 681 WP_001282919.1 WYL domain-containing protein -
LZE53_RS20980 (4276224) 4276224..4276901 + 678 WP_001097301.1 hypothetical protein -
LZE53_RS20985 (4276907) 4276907..4277140 + 234 WP_001278287.1 DUF905 family protein -
LZE53_RS20990 (4277230) 4277230..4278048 + 819 WP_001175148.1 DUF932 domain-containing protein -
LZE53_RS20995 (4278130) 4278130..4278609 + 480 WP_000844100.1 antirestriction protein -
LZE53_RS21000 (4278625) 4278625..4279101 + 477 WP_001366855.1 RadC family protein -
LZE53_RS21005 (4279164) 4279164..4279385 + 222 WP_000692309.1 DUF987 domain-containing protein -
LZE53_RS21010 (4279465) 4279465..4279839 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LZE53_RS21015 (4279886) 4279886..4280263 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
LZE53_RS21020 (4280260) 4280260..4280748 + 489 WP_000761676.1 DUF5983 family protein -
LZE53_RS21025 (4280760) 4280760..4280957 + 198 WP_000839291.1 DUF957 domain-containing protein -
LZE53_RS21030 (4281042) 4281042..4281908 + 867 WP_001280433.1 DUF4942 domain-containing protein -
LZE53_RS21035 (4281980) 4281980..4282243 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
LZE53_RS21040 (4282240) 4282240..4282566 + 327 WP_232579854.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZE53_RS21045 (4283449) 4283449..4284987 + 1539 WP_001187173.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T231248 WP_000854735.1 NZ_CP090570:4279886-4280263 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T231248 NZ_CP126166:2458378-2458776 [Salmonella enterica subsp. enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT231248 WP_001285415.1 NZ_CP090570:4279465-4279839 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT231248 NZ_CP126166:2458151-2458378 [Salmonella enterica subsp. enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References