Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 914347..914971 Replicon chromosome
Accession NC_011333
Organism Helicobacter pylori G27

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPG27_RS04365 Protein ID WP_000912776.1
Coordinates 914347..914613 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B5Z7Q4
Locus tag HPG27_RS04370 Protein ID WP_001134069.1
Coordinates 914600..914971 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPG27_RS04335 910336..911103 - 768 WP_000242349.1 ABC transporter ATP-binding protein -
HPG27_RS04340 911103..912083 - 981 WP_000921461.1 iron ABC transporter permease -
HPG27_RS04345 912076..912930 - 855 WP_000538084.1 SDR family oxidoreductase -
HPG27_RS04350 913070..913594 + 525 WP_001135628.1 acyl-CoA thioesterase -
HPG27_RS04355 913700..913971 - 272 Protein_844 type II toxin-antitoxin system YafQ family toxin -
HPG27_RS04360 913958..914269 - 312 WP_001134052.1 hypothetical protein -
HPG27_RS04365 914347..914613 - 267 WP_000912776.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPG27_RS04370 914600..914971 - 372 WP_001134069.1 hypothetical protein Antitoxin
HPG27_RS04375 915374..917596 - 2223 WP_000716234.1 outer membrane beta-barrel protein -
HPG27_RS04395 918088..918609 + 522 WP_012552496.1 hypothetical protein -
HPG27_RS04400 918560..919672 - 1113 WP_000109761.1 hydrogenase formation protein HypD -
HPG27_RS04405 919678..919911 - 234 WP_000335445.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10477.52 Da        Isoelectric Point: 10.1823

>T23124 WP_000912776.1 NC_011333:c914613-914347 [Helicobacter pylori G27]
MLKIKHHILYKKDFKKLVKNGFDDSVLNKVILTLRKKEPLDPQFQDHALKGKWKPFRECHIKPDILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T23124 NC_011333:c914613-914347 [Helicobacter pylori G27]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAGCTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAACAAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCCTAAAAGGCAAGTGGA
AACCTTTTAGGGAATGCCACATCAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14602.53 Da        Isoelectric Point: 7.2781

>AT23124 WP_001134069.1 NC_011333:c914971-914600 [Helicobacter pylori G27]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCYL
GHKIPNLETQQAMRDALNGENLETIEDFHAWANEVKKEVNAEN

Download         Length: 372 bp

>AT23124 NC_011333:c914971-914600 [Helicobacter pylori G27]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTATTTG
GGGCACAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGCGAAAACTTAGAAACTATTGAAGA
CTTTCACGCATGGGCAAATGAAGTGAAAAAGGAAGTGAATGCTGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B5Z7Q4

References