Detailed information of TA system TA231228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1271633..1272143
• Replicon: chromosome
• Accession: NZ_CP090569
• Organism: Candidatus Endoriftia persephone isolate Tica-EPR-9o50.N

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A9J7A0Z7
• Locus tag: L0Y14_RS05740
• Protein ID: WP_010086693.1
• Coordinates: 1271633..1271896 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: G2FD91
• Locus tag: L0Y14_RS05745
• Protein ID: WP_006474153.1
• Coordinates: 1271889..1272143 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y14_RS05715 (L0Y14_05715)	1266979..1267254	+	276	WP_040818982.1	hypothetical protein	-
L0Y14_RS05720 (L0Y14_05720)	1267271..1268674	+	1404	WP_006474156.1	hypothetical protein	-
L0Y14_RS05725 (L0Y14_05725)	1268691..1270817	+	2127	WP_006474155.1	hypothetical protein	-
L0Y14_RS05730 (L0Y14_05730)	1270807..1270995	+	189	WP_006474154.1	hypothetical protein	-
L0Y14_RS05735 (L0Y14_05735)	1271217..1271639	+	423	WP_050799347.1	glutaredoxin family protein	-
L0Y14_RS05740 (L0Y14_05740)	1271633..1271896	-	264	WP_010086693.1	Txe/YoeB family addiction module toxin	Toxin
L0Y14_RS05745 (L0Y14_05745)	1271889..1272143	-	255	WP_006474153.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
L0Y14_RS05750 (L0Y14_05750)	1272400..1275027	+	2628	WP_040818974.1	phage protease	-
L0Y14_RS05755 (L0Y14_05755)	1275103..1275516	+	414	WP_006474151.1	hypothetical protein	-
L0Y14_RS05760 (L0Y14_05760)	1275567..1275836	+	270	WP_040818971.1	hypothetical protein	-
L0Y14_RS05765 (L0Y14_05765)	1275833..1276261	+	429	WP_138921761.1	M23 family metallopeptidase	-
L0Y14_RS05770 (L0Y14_05770)	1276261..1276770	+	510	WP_006474148.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10330.70 Da
• Isoelectric Point: 9.4417

>T231228 WP_010086693.1 NZ_CP090569:c1271896-1271633 [Candidatus Endoriftia persephone]
MSRHLAWTEEAWADYVYWQGQDRKTLKRVNKLITDVLRTPFEGIGKPEALKQNLSGFWSRRIDDTNRLVYAVTDSHVTVI
SCRYHYQ

Nucleotide

• Length: 264 bp

>T231228 NZ_CP126140:4489783-4490094 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9598.86 Da
• Isoelectric Point: 4.6262

>AT231228 WP_006474153.1 NZ_CP090569:c1272143-1271889 [Candidatus Endoriftia persephone]
MRIVTFTEARNSLKSVLDQVIDDADCTIITRRDTEDAVVMSLEYYNGLMETVHLLRSPANAAHLEKSIEQFRQGKTVTRE
LVDE

Nucleotide

• Length: 255 bp

>AT231228 NZ_CP126140:4490091-4490537 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Antitoxin

• AlphaFold DB: G2FD91