Detailed information of TA system TA231227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2760137..2760795
• Replicon: chromosome
• Accession: NZ_CP090568
• Organism: Xanthomonas citri pv. malvacearum strain CFBP 2036

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LPY96_RS12520
• Protein ID: WP_223301037.1
• Coordinates: 2760137..2760526 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q3C002
• Locus tag: LPY96_RS12525
• Protein ID: WP_005917852.1
• Coordinates: 2760535..2760795 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPY96_RS12505 (LPY96_12520)	2757149..2758375	-	1227	WP_269338458.1	replication protein RepA	-
LPY96_RS12510 (LPY96_12525)	2758655..2759842	-	1188	WP_269338460.1	zeta toxin family protein	-
LPY96_RS12515 (LPY96_12530)	2759849..2760112	-	264	WP_005917846.1	hypothetical protein	-
LPY96_RS12520 (LPY96_12535)	2760137..2760526	-	390	WP_223301037.1	type II toxin-antitoxin system VapC family toxin	Toxin
LPY96_RS12525 (LPY96_12540)	2760535..2760795	-	261	WP_005917852.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LPY96_RS12530 (LPY96_12545)	2761145..2764429	+	3285	WP_095702083.1	type III secretion system effector avirulence protein AvrBs3	-
LPY96_RS12535 (LPY96_12550)	2764614..2765468	-	855	WP_269338461.1	putative addiction module antidote protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2734406..2778199	43793

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-118)

Antitoxin

• SpoVT-AbrB domain (8-52)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14048.32 Da
• Isoelectric Point: 6.2252

>T231227 WP_223301037.1 NZ_CP090568:c2760526-2760137 [Xanthomonas citri pv. malvacearum]
MLDTNTVSHLVKSHPAVSRRVIEVPMTALCMSAITGGELMFGLAKVPDAKRLQQAVMELLRRVDVLPWDGAVMERYGSVR
ADLEKQGKALGSLDMLIAAHALETDSVLVTNDAAFSRVVGLTVEDWTRS

Nucleotide

• Length: 390 bp

>T231227 NZ_CP126140:c4488550-4488239 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9770.95 Da
• Isoelectric Point: 5.0941

>AT231227 WP_005917852.1 NZ_CP090568:c2760795-2760535 [Xanthomonas citri pv. malvacearum]
VSQVAKLFINGRSQAVRLPAAYRFTEKEVFIRQDPETGDVILSRKPATWEDFFIALKSADVPANFLDAAERNQGTQDRDP
FAGWRE

Nucleotide

• Length: 261 bp

>AT231227 NZ_CP126140:c4488238-4487948 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Antitoxin

• AlphaFold DB: Q3C002