Detailed information of TA system TA231226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2266462..2267018
• Replicon: chromosome
• Accession: NZ_CP090568
• Organism: Xanthomonas citri pv. malvacearum strain CFBP 2036

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LPY96_RS10175
• Protein ID: WP_229637918.1
• Coordinates: 2266767..2267018 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: LPY96_RS10170
• Protein ID: WP_004541313.1
• Coordinates: 2266462..2266740 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPY96_RS10145 (LPY96_10155)	2262002..2262169	-	168	WP_005913009.1	hypothetical protein	-
LPY96_RS10155 (LPY96_10165)	2263934..2264023	-	90	Protein_1857	type I restriction-modification system subunit M N-terminal domain-containing protein	-
LPY96_RS10165 (LPY96_10175)	2265922..2266266	+	345	WP_198303413.1	hypothetical protein	-
LPY96_RS10170 (LPY96_10180)	2266462..2266740	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
LPY96_RS10175 (LPY96_10185)	2266767..2267018	+	252	WP_229637918.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPY96_RS10180 (LPY96_10190)	2267021..2267335	+	315	WP_015463310.1	hypothetical protein	-
LPY96_RS10185	2267328..2267462	+	135	WP_257608150.1	hypothetical protein	-
LPY96_RS10190 (LPY96_10195)	2267531..2267785	+	255	WP_223293127.1	hypothetical protein	-
LPY96_RS10195 (LPY96_10200)	2267998..2268533	+	536	Protein_1865	transposase	-
LPY96_RS10200 (LPY96_10205)	2268645..2271347	-	2703	Protein_1866	type III secretion system effector avirulence protein AvrBs3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2260604..2289234	28630
	-	inside	IScluster/Tn	-	-	2262256..2275003	12747

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9546.87 Da
• Isoelectric Point: 10.2314

>T231226 WP_229637918.1 NZ_CP090568:2266767-2267018 [Xanthomonas citri pv. malvacearum]
MQRLREFLKPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T231226 NZ_CP126140:c4179304-4178813 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT231226 WP_004541313.1 NZ_CP090568:2266462-2266740 [Xanthomonas citri pv. malvacearum]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT231226 NZ_CP126140:c4179594-4179301 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0