Detailed information of TA system TA231225

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): EcnAB/-
• Location: 487512..487873
• Replicon: chromosome
• Accession: NZ_CP090568
• Organism: Xanthomonas citri pv. malvacearum strain CFBP 2036

Toxin (Protein)

• Gene name: EcnB
• Uniprot ID: M4UGA1
• Locus tag: LPY96_RS02775
• Protein ID: WP_005914328.1
• Coordinates: 487739..487873 (+)
• Length: 45 a.a.

Antitoxin (Protein)

• Gene name: EcnA
• Uniprot ID: -
• Locus tag: LPY96_RS02770
• Protein ID: WP_269339739.1
• Coordinates: 487512..487664 (+)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPY96_RS02740 (LPY96_02740)	482568..483251	-	684	WP_269339735.1	dTMP kinase	-
LPY96_RS02745 (LPY96_02745)	483733..484275	-	543	WP_003486615.1	GTPase	-
LPY96_RS02750 (LPY96_02750)	484272..485189	-	918	WP_033481739.1	hypothetical protein	-
LPY96_RS02755 (LPY96_02755)	485286..485645	-	360	WP_269339736.1	roadblock/LC7 domain-containing protein	-
LPY96_RS02760 (LPY96_02760)	485709..486161	-	453	WP_269339737.1	roadblock/LC7 domain-containing protein	-
LPY96_RS02765 (LPY96_02765)	486482..487405	+	924	WP_269339738.1	arginase	-
LPY96_RS02770 (LPY96_02770)	487512..487664	+	153	WP_269339739.1	entericidin A/B family lipoprotein	Antitoxin
LPY96_RS02775 (LPY96_02775)	487739..487873	+	135	WP_005914328.1	entericidin A/B family lipoprotein	Toxin
LPY96_RS02780 (LPY96_02780)	488100..488309	+	210	WP_003486601.1	CsbD family protein	-
LPY96_RS02785 (LPY96_02785)	488491..489780	+	1290	WP_269339740.1	tryptophan--tRNA ligase	-
LPY96_RS02790 (LPY96_02790)	489909..490853	+	945	WP_269339741.1	MBL fold metallo-hydrolase	-
LPY96_RS02795 (LPY96_02795)	491045..492736	+	1692	WP_269339742.1	M28 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Entericidin A/B (23-42)

Antitoxin

• Entericidin A/B (23-42)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 4459.32 Da
• Isoelectric Point: 9.3487

>T231225 WP_005914328.1 NZ_CP090568:487739-487873 [Xanthomonas citri pv. malvacearum]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Nucleotide

• Length: 135 bp

>T231225 NZ_CP126140:c4072201-4071917 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5166.08 Da
• Isoelectric Point: 8.2782

>AT231225 WP_269339739.1 NZ_CP090568:487512-487664 [Xanthomonas citri pv. malvacearum]
MKRLLTLMVLGLFSDGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Nucleotide

• Length: 153 bp

>AT231225 NZ_CP126140:c4072433-4072191 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A3G2W7U6