Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 219185..219678 Replicon chromosome
Accession NZ_CP090568
Organism Xanthomonas citri pv. malvacearum strain CFBP 2036

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPY96_RS01670 Protein ID WP_003491151.1
Coordinates 219352..219678 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LPY96_RS01665 Protein ID WP_017157755.1
Coordinates 219185..219355 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPY96_RS01640 (LPY96_01635) 214852..216072 + 1221 WP_269339651.1 TrbI/VirB10 family protein -
LPY96_RS01645 (LPY96_01640) 216083..217105 + 1023 WP_269339652.1 P-type DNA transfer ATPase VirB11 -
LPY96_RS01650 (LPY96_01645) 217116..217985 + 870 WP_078566255.1 lytic transglycosylase domain-containing protein -
LPY96_RS01655 (LPY96_01650) 218111..218530 + 420 WP_078566256.1 hypothetical protein -
LPY96_RS01660 (LPY96_01655) 218607..218993 + 387 WP_003491149.1 hypothetical protein -
LPY96_RS01665 (LPY96_01660) 219185..219355 + 171 WP_017157755.1 antitoxin MazE family protein Antitoxin
LPY96_RS01670 (LPY96_01665) 219352..219678 + 327 WP_003491151.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPY96_RS01675 (LPY96_01670) 219747..222725 - 2979 WP_269339653.1 MobF family relaxase -
LPY96_RS01680 (LPY96_01675) 222739..224313 - 1575 WP_269339654.1 type IV secretion system DNA-binding domain-containing protein -
LPY96_RS01685 (LPY96_01680) 224317..224490 - 174 Protein_194 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 207042..225690 18648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

Antitoxin MazE-like

(2-54)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11690.73 Da        Isoelectric Point: 9.2550

>T231223 WP_003491151.1 NZ_CP090568:219352-219678 [Xanthomonas citri pv. malvacearum]
MMRGDFVTIAMQGDFGKPRPALVIQADQFDAHTTVTVLPVTSTLVAAPLLRITIHPSTDNGLQKPSQVMVDKAMTVKRDK
VGRAFGRVDADALVEIERCLAVFLGIAK

Download         Length: 327 bp

>T231223 NZ_CP126140:c3987106-3986819 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6518.34 Da        Isoelectric Point: 4.1476

>AT231223 WP_017157755.1 NZ_CP090568:219185-219355 [Xanthomonas citri pv. malvacearum]
MAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMADTDMQRFMDEALADMDGWTE

Download         Length: 171 bp

>AT231223 NZ_CP126140:c3986832-3986530 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References