231220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 67459..68117 Replicon plasmid pCFBP2012-87
Accession NZ_CP090565
Organism Xanthomonas citri pv. malvacearum strain CFBP 2012

Toxin (Protein)


Gene name vapC Uniprot ID Q8PRH3
Locus tag LPY95_RS22490 Protein ID WP_011053002.1
Coordinates 67459..67860 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q3C002
Locus tag LPY95_RS22495 Protein ID WP_005917852.1
Coordinates 67857..68117 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPY95_RS22475 (LPY95_22505) 64471..65697 - 1227 WP_269360339.1 replication protein RepA -
LPY95_RS22480 (LPY95_22510) 65977..67164 - 1188 WP_269360341.1 zeta toxin family protein -
LPY95_RS22485 (LPY95_22515) 67171..67434 - 264 WP_005917846.1 hypothetical protein -
LPY95_RS22490 (LPY95_22520) 67459..67860 - 402 WP_011053002.1 type II toxin-antitoxin system VapC family toxin Toxin
LPY95_RS22495 (LPY95_22525) 67857..68117 - 261 WP_005917852.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LPY95_RS22500 (LPY95_22530) 68467..72060 + 3594 WP_095702115.1 type III secretion system effector avirulence protein AvrBs3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..86622 86622


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(8-52)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14627.05 Da        Isoelectric Point: 7.2785

>T231220 WP_011053002.1 NZ_CP090565:c67860-67459 [Xanthomonas citri pv. malvacearum]
MKRYMLDTNTVSHLVKSHPAVSRRVIEVPMTALCMSAITGGELMFGLAKVPDAKRLQQAVMELLRRVDVLPWDGAVMERY
GSVRADLEKQGKALGSLDMLIAAHALETDSVLVTNDAAFSRVVGLTVEDWTRS

Download         Length: 402 bp

>T231220 NZ_CP126140:c2693111-2693008 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9770.95 Da        Isoelectric Point: 5.0941

>AT231220 WP_005917852.1 NZ_CP090565:c68117-67857 [Xanthomonas citri pv. malvacearum]
VSQVAKLFINGRSQAVRLPAAYRFTEKEVFIRQDPETGDVILSRKPATWEDFFIALKSADVPANFLDAAERNQGTQDRDP
FAGWRE

Download         Length: 261 bp

>AT231220 NZ_CP126140:2693006-2693151 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8PRH3

Antitoxin

Source ID Structure
AlphaFold DB Q3C002

References