Detailed information of TA system TA023122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 328012..328696
• Replicon: chromosome
• Accession: NC_011333
• Organism: Helicobacter pylori G27

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPG27_RS01585
• Protein ID: WP_000912777.1
• Coordinates: 328012..328338 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B5Z7Q4
• Locus tag: HPG27_RS01590
• Protein ID: WP_001134069.1
• Coordinates: 328325..328696 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPG27_RS01560	323288..323977	-	690	WP_000270095.1	hypothetical protein	-
HPG27_RS01565	323977..325094	-	1118	Protein_294	site-specific DNA-methyltransferase	-
HPG27_RS01570	325188..325556	+	369	WP_000337921.1	hypothetical protein	-
HPG27_RS01575	325556..326518	+	963	WP_001124288.1	GTP-binding protein	-
HPG27_RS01580	326524..327669	-	1146	WP_001263623.1	YbfB/YjiJ family MFS transporter	-
HPG27_RS01585	328012..328338	-	327	WP_000912777.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPG27_RS01590	328325..328696	-	372	WP_001134069.1	hypothetical protein	Antitoxin
HPG27_RS01595	329099..331333	-	2235	WP_000716273.1	Hop family adhesin BabA	-
HPG27_RS01600	331602..332357	-	756	WP_000934615.1	HugZ family heme oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12686.20 Da
• Isoelectric Point: 10.4541

>T23122 WP_000912777.1 NC_011333:c328338-328012 [Helicobacter pylori G27]
MLKIKHHILYKKDFKKLVKNGFDDSVLNKVILTLRKKEPLDPQFQDHALKGKWKPFRECHIKPDILLVYLVKDDELILLR
LGSHSELFYKPPITLKKNTTIAVNSKPL

Nucleotide

• Length: 327 bp

>T23122 NC_011333:c328338-328012 [Helicobacter pylori G27]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAGCTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAACAAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCCTAAAAGGCAAGTGGA
AACCTTTTAGGGAATGCCACATCAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTATAAACCACCCATAACGCTTAAAAAGAACACAACAATCGCAGTTAACTCTAAACC
GCTATAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 14602.53 Da
• Isoelectric Point: 7.2781

>AT23122 WP_001134069.1 NC_011333:c328696-328325 [Helicobacter pylori G27]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCYL
GHKIPNLETQQAMRDALNGENLETIEDFHAWANEVKKEVNAEN

Nucleotide

• Length: 372 bp

>AT23122 NC_011333:c328696-328325 [Helicobacter pylori G27]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTATTTG
GGGCACAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGCGAAAACTTAGAAACTATTGAAGA
CTTTCACGCATGGGCAAATGAAGTGAAAAAGGAAGTGAATGCTGAAAATTAA

Structures

Antitoxin

• AlphaFold DB: B5Z7Q4