Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2681127..2681785 Replicon chromosome
Accession NZ_CP090564
Organism Xanthomonas citri pv. malvacearum strain CFBP 2012

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LPY95_RS11370 Protein ID WP_223301037.1
Coordinates 2681127..2681516 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q3C002
Locus tag LPY95_RS11375 Protein ID WP_005917852.1
Coordinates 2681525..2681785 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPY95_RS11355 (LPY95_11365) 2678139..2679365 - 1227 WP_269358111.1 replication protein RepA -
LPY95_RS11360 (LPY95_11370) 2679645..2680832 - 1188 WP_269358112.1 zeta toxin family protein -
LPY95_RS11365 (LPY95_11375) 2680839..2681102 - 264 WP_005917846.1 hypothetical protein -
LPY95_RS11370 (LPY95_11380) 2681127..2681516 - 390 WP_223301037.1 type II toxin-antitoxin system VapC family toxin Toxin
LPY95_RS11375 (LPY95_11385) 2681525..2681785 - 261 WP_005917852.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LPY95_RS11380 (LPY95_11390) 2682135..2685419 + 3285 WP_095702083.1 type III secretion system effector avirulence protein AvrBs3 -
LPY95_RS11385 (LPY95_11395) 2685604..2686455 - 852 WP_033837071.1 putative addiction module antidote protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2662134..2706273 44139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-118)

Antitoxin

SpoVT-AbrB domain

(8-52)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14048.32 Da        Isoelectric Point: 6.2252

>T231219 WP_223301037.1 NZ_CP090564:c2681516-2681127 [Xanthomonas citri pv. malvacearum]
MLDTNTVSHLVKSHPAVSRRVIEVPMTALCMSAITGGELMFGLAKVPDAKRLQQAVMELLRRVDVLPWDGAVMERYGSVR
ADLEKQGKALGSLDMLIAAHALETDSVLVTNDAAFSRVVGLTVEDWTRS

Download         Length: 390 bp

>T231219 NZ_CP126140:c2443643-2443488 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9770.95 Da        Isoelectric Point: 5.0941

>AT231219 WP_005917852.1 NZ_CP090564:c2681785-2681525 [Xanthomonas citri pv. malvacearum]
VSQVAKLFINGRSQAVRLPAAYRFTEKEVFIRQDPETGDVILSRKPATWEDFFIALKSADVPANFLDAAERNQGTQDRDP
FAGWRE

Download         Length: 261 bp

>AT231219 NZ_CP126140:2443655-2443713 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q3C002

References