Detailed information of TA system TA231218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2265195..2265751
• Replicon: chromosome
• Accession: NZ_CP090564
• Organism: Xanthomonas citri pv. malvacearum strain CFBP 2012

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LPY95_RS09455
• Protein ID: WP_229637918.1
• Coordinates: 2265500..2265751 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: LPY95_RS09450
• Protein ID: WP_004541313.1
• Coordinates: 2265195..2265473 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPY95_RS09425 (LPY95_09435)	2260734..2260901	-	168	WP_005913009.1	hypothetical protein	-
LPY95_RS09435 (LPY95_09445)	2262667..2262756	-	90	Protein_1852	type I restriction-modification system subunit M N-terminal domain-containing protein	-
LPY95_RS09445 (LPY95_09455)	2264655..2264999	+	345	WP_198303413.1	hypothetical protein	-
LPY95_RS09450 (LPY95_09460)	2265195..2265473	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
LPY95_RS09455 (LPY95_09465)	2265500..2265751	+	252	WP_229637918.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPY95_RS09460 (LPY95_09470)	2265754..2266068	+	315	WP_015463310.1	hypothetical protein	-
LPY95_RS09465	2266061..2266195	+	135	WP_257608150.1	hypothetical protein	-
LPY95_RS09470 (LPY95_09475)	2266264..2266518	+	255	WP_223293127.1	hypothetical protein	-
LPY95_RS09475 (LPY95_09480)	2266731..2267266	+	536	Protein_1860	transposase	-
LPY95_RS09480 (LPY95_09485)	2267378..2270080	-	2703	Protein_1861	type III secretion system effector avirulence protein AvrBs3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2248094..2287967	39873
	-	inside	IScluster/Tn	-	-	2260988..2273736	12748

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9546.87 Da
• Isoelectric Point: 10.2314

>T231218 WP_229637918.1 NZ_CP090564:2265500-2265751 [Xanthomonas citri pv. malvacearum]
MQRLREFLKPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T231218 NZ_CP126140:c989037-988510 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT231218 WP_004541313.1 NZ_CP090564:2265195-2265473 [Xanthomonas citri pv. malvacearum]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT231218 NZ_CP126140:c989324-989034 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0