Detailed information of TA system TA231217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): EcnAB/-
• Location: 485729..486090
• Replicon: chromosome
• Accession: NZ_CP090564
• Organism: Xanthomonas citri pv. malvacearum strain CFBP 2012

Toxin (Protein)

• Gene name: EcnB
• Uniprot ID: M4UGA1
• Locus tag: LPY95_RS02055
• Protein ID: WP_005914328.1
• Coordinates: 485956..486090 (+)
• Length: 45 a.a.

Antitoxin (Protein)

• Gene name: EcnA
• Uniprot ID: -
• Locus tag: LPY95_RS02050
• Protein ID: WP_269359343.1
• Coordinates: 485729..485881 (+)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPY95_RS02020 (LPY95_02020)	480785..481468	-	684	WP_269359339.1	dTMP kinase	-
LPY95_RS02025 (LPY95_02025)	481950..482492	-	543	WP_003486615.1	GTPase	-
LPY95_RS02030 (LPY95_02030)	482489..483406	-	918	WP_033481739.1	hypothetical protein	-
LPY95_RS02035 (LPY95_02035)	483503..483862	-	360	WP_003486613.1	hypothetical protein	-
LPY95_RS02040 (LPY95_02040)	483926..484378	-	453	WP_269359341.1	roadblock/LC7 domain-containing protein	-
LPY95_RS02045 (LPY95_02045)	484699..485622	+	924	WP_269339738.1	arginase	-
LPY95_RS02050 (LPY95_02050)	485729..485881	+	153	WP_269359343.1	entericidin A/B family lipoprotein	Antitoxin
LPY95_RS02055 (LPY95_02055)	485956..486090	+	135	WP_005914328.1	entericidin A/B family lipoprotein	Toxin
LPY95_RS02060 (LPY95_02060)	486317..486526	+	210	WP_003486601.1	CsbD family protein	-
LPY95_RS02065 (LPY95_02065)	486708..487996	+	1289	Protein_406	tryptophan--tRNA ligase	-
LPY95_RS02070 (LPY95_02070)	488125..489069	+	945	WP_005914330.1	MBL fold metallo-hydrolase	-
LPY95_RS02075 (LPY95_02075)	489261..490952	+	1692	WP_269359345.1	M28 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Entericidin A/B (23-42)

Antitoxin

• Entericidin A/B (23-41)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 4459.32 Da
• Isoelectric Point: 9.3487

>T231217 WP_005914328.1 NZ_CP090564:485956-486090 [Xanthomonas citri pv. malvacearum]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Nucleotide

• Length: 135 bp

>T231217 NZ_CP126140:836168-836566 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5138.07 Da
• Isoelectric Point: 8.7942

>AT231217 WP_269359343.1 NZ_CP090564:485729-485881 [Xanthomonas citri pv. malvacearum]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTSEKCSDGKC

Nucleotide

• Length: 153 bp

>AT231217 NZ_CP126140:835941-836168 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• AlphaFold DB: A0A3G2W7U6