Detailed information of TA system TA231216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 226294..226831
• Replicon: chromosome
• Accession: NZ_CP090564
• Organism: Xanthomonas citri pv. malvacearum strain CFBP 2012

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7X9YU06
• Locus tag: LPY95_RS01000
• Protein ID: WP_017158383.1
• Coordinates: 226294..226575 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7X9UWY6
• Locus tag: LPY95_RS01005
• Protein ID: WP_017158384.1
• Coordinates: 226562..226831 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPY95_RS00970 (LPY95_00970)	222100..223674	-	1575	WP_269359205.1	type IV secretion system DNA-binding domain-containing protein	-
LPY95_RS00975 (LPY95_00975)	223678..223851	-	174	Protein_191	hypothetical protein	-
LPY95_RS00980 (LPY95_00980)	223851..224246	-	396	WP_269359207.1	conjugal transfer protein TraA	-
LPY95_RS00985 (LPY95_00985)	224605..225051	+	447	WP_017160486.1	hypothetical protein	-
LPY95_RS00990 (LPY95_00990)	225060..225755	+	696	WP_269356287.1	StbB family protein	-
LPY95_RS00995 (LPY95_00995)	225803..226156	+	354	WP_269339657.1	hypothetical protein	-
LPY95_RS01000 (LPY95_01000)	226294..226575	-	282	WP_017158383.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LPY95_RS01005 (LPY95_01005)	226562..226831	-	270	WP_017158384.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPY95_RS01010 (LPY95_01010)	226940..227902	-	963	WP_007968792.1	recombinase family protein	-
LPY95_RS01015 (LPY95_01015)	228172..228340	-	169	Protein_199	KfrA protein	-
LPY95_RS01020 (LPY95_01020)	228454..228735	-	282	WP_017161425.1	hypothetical protein	-
LPY95_RS01025 (LPY95_01025)	228759..229409	-	651	WP_223304348.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-93)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-86)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10679.06 Da
• Isoelectric Point: 8.9188

>T231216 WP_017158383.1 NZ_CP090564:c226575-226294 [Xanthomonas citri pv. malvacearum]
MRTIDRSSAFKRDYKREAKGQHRATLDDAIKPVLVALATDQPPDARYRDHDLSGDWAGYRECHIKPDLLLIYRKSDPDTL
RLARLGSHSELFG

Nucleotide

• Length: 282 bp

>T231216 NZ_CP126140:825264-825677 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9719.10 Da
• Isoelectric Point: 5.6976

>AT231216 WP_017158384.1 NZ_CP090564:c226831-226562 [Xanthomonas citri pv. malvacearum]
MSTTADTYVRARIDTATKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNTTTKKAIAELESGKGKKFANVDD
LMADLHADD

Nucleotide

• Length: 270 bp

>AT231216 NZ_CP126140:825017-825283 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A7X9YU06

Antitoxin

• AlphaFold DB: A0A7X9UWY6