Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 217021..217514 Replicon chromosome
Accession NZ_CP090564
Organism Xanthomonas citri pv. malvacearum strain CFBP 2012

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPY95_RS00950 Protein ID WP_007968778.1
Coordinates 217188..217514 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LPY95_RS00945 Protein ID WP_017158763.1
Coordinates 217021..217191 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPY95_RS00915 (LPY95_00915) 212768..213790 + 1023 WP_269359198.1 P-type DNA transfer ATPase VirB11 -
LPY95_RS00920 (LPY95_00920) 213801..214688 + 888 WP_269360175.1 lytic transglycosylase domain-containing protein -
LPY95_RS00925 (LPY95_00925) 214734..215321 + 588 WP_269359200.1 hypothetical protein -
LPY95_RS00930 (LPY95_00930) 215367..215942 + 576 WP_039582731.1 phospholipase D family protein -
LPY95_RS00935 (LPY95_00935) 215953..216366 + 414 WP_269359201.1 hypothetical protein -
LPY95_RS00940 (LPY95_00940) 216420..216836 + 417 WP_017159868.1 hypothetical protein -
LPY95_RS00945 (LPY95_00945) 217021..217191 + 171 WP_017158763.1 antitoxin MazE family protein Antitoxin
LPY95_RS00950 (LPY95_00950) 217188..217514 + 327 WP_007968778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPY95_RS00955 (LPY95_00955) 217560..218204 - 645 WP_039580900.1 Abi family protein -
LPY95_RS00960 (LPY95_00960) 218792..219040 + 249 Protein_188 type II toxin-antitoxin system PemK/MazF family toxin -
LPY95_RS00965 (LPY95_00965) 219109..222086 - 2978 Protein_189 conjugative relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 204553..225051 20498


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

Antitoxin MazE-like

(2-54)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11732.81 Da        Isoelectric Point: 9.2550

>T231215 WP_007968778.1 NZ_CP090564:217188-217514 [Xanthomonas citri pv. malvacearum]
MMRGDFVTIAMQGDFGKPRPALVIQANQFDEHTTVTVLPVTSTLVAAPLLRITVHPSTDNGLLKPSQVMVDKAMTVKRDK
IGRAFGRVDADALVEIERCLAVFLGIAK

Download         Length: 327 bp

>T231215 NZ_CP126140:358934-359209 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6576.38 Da        Isoelectric Point: 4.0785

>AT231215 WP_017158763.1 NZ_CP090564:217021-217191 [Xanthomonas citri pv. malvacearum]
MAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMEDTDMQRFMDEALADMDGWTE

Download         Length: 171 bp

>AT231215 NZ_CP126140:358671-358931 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References