Detailed information of TA system TA231210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2267222..2267778
• Replicon: chromosome
• Accession: NZ_CP090561
• Organism: Xanthomonas citri pv. malvacearum strain CFBP 2530

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LGM68_RS09475
• Protein ID: WP_229637918.1
• Coordinates: 2267527..2267778 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: LGM68_RS09470
• Protein ID: WP_004541313.1
• Coordinates: 2267222..2267500 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM68_RS09445 (LGM68_09450)	2262761..2262928	-	168	WP_005913009.1	hypothetical protein	-
LGM68_RS09455 (LGM68_09460)	2264694..2264783	-	90	Protein_1856	type I restriction-modification system subunit M N-terminal domain-containing protein	-
LGM68_RS09465 (LGM68_09470)	2266682..2267026	+	345	WP_198303413.1	hypothetical protein	-
LGM68_RS09470 (LGM68_09475)	2267222..2267500	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
LGM68_RS09475 (LGM68_09480)	2267527..2267778	+	252	WP_229637918.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGM68_RS09480 (LGM68_09485)	2267781..2268095	+	315	WP_015463310.1	hypothetical protein	-
LGM68_RS09485	2268088..2268222	+	135	WP_257608150.1	hypothetical protein	-
LGM68_RS09490 (LGM68_09490)	2268291..2268545	+	255	WP_223293127.1	hypothetical protein	-
LGM68_RS09495 (LGM68_09495)	2268758..2269293	+	536	Protein_1864	transposase	-
LGM68_RS09500 (LGM68_09500)	2269405..2272107	-	2703	Protein_1865	type III secretion system effector avirulence protein AvrBs3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2241926..2315232	73306
	-	inside	IScluster/Tn	-	-	2263015..2275763	12748

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9546.87 Da
• Isoelectric Point: 10.2314

>T231210 WP_229637918.1 NZ_CP090561:2267527-2267778 [Xanthomonas citri pv. malvacearum]
MQRLREFLKPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T231210 NZ_CP126138:4699288-4699599 [Salmonella enterica subsp. enterica serovar Kottbus]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT231210 WP_004541313.1 NZ_CP090561:2267222-2267500 [Xanthomonas citri pv. malvacearum]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT231210 NZ_CP126138:4699596-4700042 [Salmonella enterica subsp. enterica serovar Kottbus]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Antitoxin

• AlphaFold DB: M4UBZ0