Detailed information of TA system TA023121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 613475..614264
• Replicon: chromosome
• Accession: NC_011313
• Organism: Aliivibrio salmonicida LFI1238

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: -
• Locus tag: VSAL_RS18965
• Protein ID: WP_012551881.1
• Coordinates: 613475..613732 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: B6ERI0
• Locus tag: VSAL_RS18970
• Protein ID: WP_012551882.1
• Coordinates: 613740..614264 (+)
• Length: 175 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VSAL_RS23575	608674..608847	+	174	WP_012551875.1	hypothetical protein	-
VSAL_RS18945	609002..609886	+	885	WP_012551876.1	GIY-YIG nuclease family protein	-
VSAL_RS18950	610662..610913	+	252	WP_012551877.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
VSAL_RS18955	610910..611170	+	261	WP_012551878.1	Txe/YoeB family addiction module toxin	-
VSAL_RS18960	611947..613092	+	1146	WP_012551880.1	IS91-like element ISVsa10 family transposase	-
VSAL_RS18965	613475..613732	+	258	WP_012551881.1	DUF4160 domain-containing protein	Toxin
VSAL_RS18970	613740..614264	+	525	WP_012551882.1	DUF2442 domain-containing protein	Antitoxin
VSAL_RS18975	614957..615361	+	405	WP_012551883.1	hypothetical protein	-
VSAL_RS18985	615528..616672	+	1145	WP_085941879.1	IS3 family transposase	-
VSAL_RS23010	616741..616977	+	237	Protein_571	transposase	-
VSAL_RS18990	617151..617399	+	249	WP_012551886.1	DUF3297 family protein	-
VSAL_RS18995	617672..618961	+	1290	WP_044583649.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	611947..616672	4725
	-	inside	Integron	-	-	593499..615361	21862

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-73)

Antitoxin

• Protein of unknown function DUF2442 (4-67)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9727.41 Da
• Isoelectric Point: 8.4957

>T23121 WP_012551881.1 NC_011313:613475-613732 [Aliivibrio salmonicida LFI1238]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAEAHIESNRVKLMAMWKQAVAGI
NPGKL

Nucleotide

• Length: 258 bp

>T23121 NC_011313:613475-613732 [Aliivibrio salmonicida LFI1238]
ATGCCAGAGATAGATGCATTGCTTGGGCTTTCATTTTGTCTGTATTTTTTCGATAACAAGCAGCATAAATTGCCTCATAT
TCATGTCAAATATGGTAGCTATGAGCTAATTATAGCAATTGAAACAGGTGAGTGCTTAGAGGGTTATTTACCAAATAAGC
AACGAAAACGAGCAGAAGCTCACATTGAAAGCAATCGAGTAAAATTGATGGCAATGTGGAAACAAGCAGTTGCTGGTATT
AATCCGGGTAAATTATAG

Antitoxin

Protein

• Length: 175 a.a.
• Molecular weight: 19207.66 Da
• Isoelectric Point: 4.7233

>AT23121 WP_012551882.1 NC_011313:613740-614264 [Aliivibrio salmonicida LFI1238]
MLKVIDVDLVANFTLELTFSDGYTGEANLTEYFQKEAFSHVANFQKFALTADGSLDWSGAELSAATLKEITVGSYTESDL
TPFDVKEMEMVIKQASWDSMQEGRADILQAAIRSYVEQFGHSVVIERAGIKSRTSAYRSLKPETTPSFGTLVQLGHAVIE
LAKDRVSAHSLSRM

Nucleotide

• Length: 525 bp

>AT23121 NC_011313:613740-614264 [Aliivibrio salmonicida LFI1238]
ATGTTGAAAGTAATTGATGTTGATTTGGTAGCTAATTTTACACTTGAGCTTACTTTTAGTGACGGTTATACCGGTGAAGC
AAACTTAACTGAGTATTTCCAAAAAGAAGCATTTAGCCATGTGGCTAATTTTCAAAAGTTTGCATTAACGGCTGACGGCT
CTCTTGATTGGAGTGGTGCTGAATTATCTGCTGCAACGTTAAAAGAAATCACGGTTGGTAGTTATACTGAATCTGATTTA
ACGCCTTTTGACGTTAAAGAAATGGAAATGGTAATCAAGCAGGCTTCATGGGATTCAATGCAAGAAGGTCGAGCTGACAT
TTTGCAAGCGGCCATTCGTTCTTATGTTGAACAATTTGGCCACAGTGTTGTAATTGAGCGTGCAGGAATTAAAAGTAGAA
CGAGTGCTTATCGTTCATTAAAACCTGAAACGACACCAAGTTTTGGTACTTTGGTTCAATTAGGGCATGCAGTAATTGAG
TTGGCTAAAGATAGAGTATCTGCTCATTCTTTGAGTCGCATGTAA

Structures

Antitoxin

• AlphaFold DB: B6ERI0