Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 213945..214438 Replicon chromosome
Accession NZ_CP090561
Organism Xanthomonas citri pv. malvacearum strain CFBP 2530

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LGM68_RS00945 Protein ID WP_003491151.1
Coordinates 214112..214438 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LGM68_RS00940 Protein ID WP_017157755.1
Coordinates 213945..214115 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM68_RS00915 (LGM68_00910) 209613..210833 + 1221 WP_269356279.1 TrbI/VirB10 family protein -
LGM68_RS00920 (LGM68_00915) 210844..211866 + 1023 WP_269356281.1 P-type DNA transfer ATPase VirB11 -
LGM68_RS00925 (LGM68_00920) 211877..212746 + 870 WP_269357482.1 transglycosylase SLT domain-containing protein -
LGM68_RS00930 (LGM68_00925) 212872..213291 + 420 WP_078566256.1 hypothetical protein -
LGM68_RS00935 (LGM68_00930) 213368..213754 + 387 WP_003491149.1 hypothetical protein -
LGM68_RS00940 (LGM68_00935) 213945..214115 + 171 WP_017157755.1 antitoxin MazE family protein Antitoxin
LGM68_RS00945 (LGM68_00940) 214112..214438 + 327 WP_003491151.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LGM68_RS00950 (LGM68_00945) 214507..217486 - 2980 Protein_186 conjugative relaxase -
LGM68_RS00955 (LGM68_00950) 217500..219074 - 1575 WP_269356283.1 type IV secretion system DNA-binding domain-containing protein -
LGM68_RS00960 (LGM68_00955) 219078..219251 - 174 Protein_188 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 201281..224987 23706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

Antitoxin MazE-like

(2-54)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11690.73 Da        Isoelectric Point: 9.2550

>T231207 WP_003491151.1 NZ_CP090561:214112-214438 [Xanthomonas citri pv. malvacearum]
MMRGDFVTIAMQGDFGKPRPALVIQADQFDAHTTVTVLPVTSTLVAAPLLRITIHPSTDNGLQKPSQVMVDKAMTVKRDK
VGRAFGRVDADALVEIERCLAVFLGIAK

Download         Length: 327 bp

>T231207 NZ_CP126138:c4248866-4248582 [Salmonella enterica subsp. enterica serovar Kottbus]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6518.34 Da        Isoelectric Point: 4.1476

>AT231207 WP_017157755.1 NZ_CP090561:213945-214115 [Xanthomonas citri pv. malvacearum]
MAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMADTDMQRFMDEALADMDGWTE

Download         Length: 171 bp

>AT231207 NZ_CP126138:c4249098-4248856 [Salmonella enterica subsp. enterica serovar Kottbus]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References