23120

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 610662..611170 Replicon chromosome
Accession NC_011313
Organism Aliivibrio salmonicida LFI1238

Toxin (Protein)


Gene name relB Uniprot ID B6ERH6
Locus tag VSAL_RS18955 Protein ID WP_012551878.1
Coordinates 610910..611170 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B6ERH5
Locus tag VSAL_RS18950 Protein ID WP_012551877.1
Coordinates 610662..610913 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VSAL_RS18935 606153..607745 - 1593 WP_012551872.1 RNA-directed DNA polymerase -
VSAL_RS23570 608314..608508 - 195 WP_012551874.1 hypothetical protein -
VSAL_RS23575 608674..608847 + 174 WP_012551875.1 hypothetical protein -
VSAL_RS18945 609002..609886 + 885 WP_012551876.1 GIY-YIG nuclease family protein -
VSAL_RS18950 610662..610913 + 252 WP_012551877.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
VSAL_RS18955 610910..611170 + 261 WP_012551878.1 Txe/YoeB family addiction module toxin Toxin
VSAL_RS18960 611947..613092 + 1146 WP_012551880.1 IS91-like element ISVsa10 family transposase -
VSAL_RS18965 613475..613732 + 258 WP_012551881.1 DUF4160 domain-containing protein -
VSAL_RS18970 613740..614264 + 525 WP_012551882.1 DUF2442 domain-containing protein -
VSAL_RS18975 614957..615361 + 405 WP_012551883.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 611947..616672 4725
- inside Integron - - 593499..615361 21862


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10249.68 Da        Isoelectric Point: 8.8610

>T23120 WP_012551878.1 NC_011313:610910-611170 [Aliivibrio salmonicida LFI1238]
MSRMLAWTDDAWDDYLYWQGQDKKTLKRINKLITDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVNDAHLTII
SCRYHY

Download         Length: 261 bp

>T23120 NC_011313:610910-611170 [Aliivibrio salmonicida LFI1238]
ATGAGTCGAATGTTAGCTTGGACTGACGATGCTTGGGATGATTACTTGTATTGGCAAGGTCAGGATAAGAAAACGCTGAA
ACGCATCAATAAATTAATTACTGATGTGAAGCGTTCTCCCTTCGAAGGTATTGGTAAACCTGAGCCATTGAAAGAAAATT
TGGCAGGTTTTTGGTCACGTAGAATTGATGACACCAACCGATTAGTTTATGCAGTTAATGATGCACATTTGACAATAATT
TCCTGTCGCTATCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9189.31 Da        Isoelectric Point: 4.6683

>AT23120 WP_012551877.1 NC_011313:610662-610913 [Aliivibrio salmonicida LFI1238]
MRIVSFTEARNGLKSVLDGVVNDADCTVITRRDSEDAVVMSMDYYNSLMETIYLSRSPANAAHLNKSIAQYNAGQTTERG
LLE

Download         Length: 252 bp

>AT23120 NC_011313:610662-610913 [Aliivibrio salmonicida LFI1238]
ATGCGTATAGTTTCTTTTACTGAAGCTCGAAATGGTCTTAAATCTGTTCTTGATGGCGTAGTTAATGATGCGGACTGCAC
AGTTATCACTCGTCGAGATTCTGAAGATGCAGTTGTAATGTCTATGGATTATTATAATAGCTTAATGGAAACGATTTATT
TATCTCGTTCTCCAGCTAATGCTGCTCATCTAAACAAATCAATTGCTCAATACAATGCTGGTCAAACTACGGAAAGAGGC
TTGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6ERH6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9PEW0

References