Detailed information of TA system TA023119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 605386..605926
• Replicon: chromosome
• Accession: NC_011313
• Organism: Aliivibrio salmonicida LFI1238

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B6ERG8
• Locus tag: VSAL_RS18925
• Protein ID: WP_012551870.1
• Coordinates: 605386..605655 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B6ERG9
• Locus tag: VSAL_RS18930
• Protein ID: WP_012551871.1
• Coordinates: 605648..605926 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VSAL_RS18885	600548..600817	+	270	WP_044583569.1	DUF1778 domain-containing protein	-
VSAL_RS18890	600814..601344	+	531	WP_012551863.1	GNAT family N-acetyltransferase	-
VSAL_RS18895	601353..602048	+	696	WP_012551864.1	hypothetical protein	-
VSAL_RS18900	602236..602490	+	255	WP_012551865.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
VSAL_RS18905	602481..602795	+	315	WP_012551866.1	type II toxin-antitoxin system RelE/ParE family toxin	-
VSAL_RS18910	603039..603389	+	351	WP_012551867.1	cupin domain-containing protein	-
VSAL_RS18915	603629..604099	+	471	WP_012551868.1	hypothetical protein	-
VSAL_RS18920	604092..604694	+	603	WP_012551869.1	putative adenosine monophosphate-protein transferase Fic	-
VSAL_RS18925	605386..605655	-	270	WP_012551870.1	type II toxin-antitoxin system YafQ family toxin	Toxin
VSAL_RS18930	605648..605926	-	279	WP_012551871.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
VSAL_RS18935	606153..607745	-	1593	WP_012551872.1	RNA-directed DNA polymerase	-
VSAL_RS23570	608314..608508	-	195	WP_012551874.1	hypothetical protein	-
VSAL_RS23575	608674..608847	+	174	WP_012551875.1	hypothetical protein	-
VSAL_RS18945	609002..609886	+	885	WP_012551876.1	GIY-YIG nuclease family protein	-
VSAL_RS18950	610662..610913	+	252	WP_012551877.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	593499..615361	21862

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-84)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10355.92 Da
• Isoelectric Point: 8.9467

>T23119 WP_012551870.1 NC_011313:c605655-605386 [Aliivibrio salmonicida LFI1238]
MYNLEYSTQFKKDFKKITKMPISNIIEVGNIISKLQRNETLDPKNVDHSLTGNWSGFRDCHIKPDLVLIYRIFDGQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T23119 NC_011313:c605655-605386 [Aliivibrio salmonicida LFI1238]
ATGTATAACCTAGAATACTCCACGCAATTTAAAAAGGATTTTAAGAAGATAACTAAAATGCCAATCTCCAATATCATCGA
AGTTGGCAATATCATCTCAAAATTACAAAGAAATGAAACATTAGACCCTAAAAATGTAGATCATTCTTTAACGGGAAATT
GGAGTGGTTTTCGCGACTGTCATATAAAACCAGACTTAGTTCTCATTTACCGTATATTTGATGGGCAACTACAACTAGCA
AGAATTGGGTCACATAGCGATCTATTTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10029.47 Da
• Isoelectric Point: 6.2167

>AT23119 WP_012551871.1 NC_011313:c605926-605648 [Aliivibrio salmonicida LFI1238]
MRNEMLSTRIDHDTKLAFTSICGEVGLSTSQAIKLFAKAVINHGGIPFDLRVPQPNEVSAAAMKELVENKGHKANSIDEM
FSELTEGKVTNV

Nucleotide

• Length: 279 bp

>AT23119 NC_011313:c605926-605648 [Aliivibrio salmonicida LFI1238]
ATGAGAAATGAAATGCTAAGCACCCGCATAGACCATGATACCAAACTTGCTTTCACTAGCATCTGCGGTGAAGTTGGCCT
AAGCACATCACAAGCAATTAAACTATTTGCTAAAGCTGTCATTAACCATGGTGGTATTCCATTTGATCTACGAGTTCCGC
AGCCAAATGAAGTTTCTGCTGCTGCAATGAAAGAACTTGTTGAAAATAAAGGACATAAAGCCAACTCTATAGATGAGATG
TTTTCTGAGCTCACTGAAGGCAAAGTGACAAATGTATAA

Structures

Toxin

• AlphaFold DB: B6ERG8

Antitoxin

• AlphaFold DB: B6ERG9