Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 1144346..1145055 Replicon chromosome
Accession NZ_CP090556
Organism Actinobacillus suis strain D20_277

Toxin (Protein)


Gene name vapC Uniprot ID K0G9D3
Locus tag L0F67_RS05800 Protein ID WP_014990917.1
Coordinates 1144633..1145055 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID K0G3K1
Locus tag L0F67_RS05795 Protein ID WP_014990916.1
Coordinates 1144346..1144633 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F67_RS05780 (L0F67_05765) 1139747..1140928 + 1182 WP_014990913.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
L0F67_RS05785 (L0F67_05770) 1140983..1141530 + 548 Protein_1094 type IV pilus biogenesis/stability protein PilW -
L0F67_RS05790 (L0F67_05775) 1141606..1143944 + 2339 Protein_1095 RNA-binding transcriptional accessory protein -
L0F67_RS05795 (L0F67_05780) 1144346..1144633 + 288 WP_014990916.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0F67_RS05800 (L0F67_05785) 1144633..1145055 + 423 WP_014990917.1 type II toxin-antitoxin system VapC family toxin Toxin
L0F67_RS05805 (L0F67_05790) 1145430..1146710 - 1281 WP_014990918.1 NAD(P)/FAD-dependent oxidoreductase -
L0F67_RS05810 (L0F67_05795) 1146822..1147340 - 519 WP_179130574.1 SprT family zinc-dependent metalloprotease -
L0F67_RS05815 (L0F67_05800) 1147341..1148111 - 771 WP_014990920.1 ribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16233.07 Da        Isoelectric Point: 9.0431

>T231187 WP_014990917.1 NZ_CP090556:1144633-1145055 [Actinobacillus suis]
MYLLDTNIVSELRKMESGKADVNVVAWFQQVNLTDAYLSVITLFEIKLGILQLKRKDIQQAKLLQSWFEQKLLHHFENRI
LPLDTKVMMICAEFHIPDKKPLNDSYIAATAKAHRFKIVTRNVKNFKGCGVEVLNPFIDE

Download         Length: 423 bp

>T231187 NZ_CP126114:357321-357671 [Neobacillus novalis]
TTGATTGTCAAGCGTGGTGACGTTTATTTCGCGGACCTATCCCCAGTTGTTGGTTCTGAACAAGGCGGCGTCCGACCTGT
ACTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTGTTGCAGCGATTACAGCTCAAATTCAAAAAG
CGAAGCTTCCAACTCATGTAGAAATTGATGCGAAGCGCTACGGATTTGAGCGAGATTCGGTCATTCTGTTAGAGCAAATT
CGTACAATTGATAAGCAGCGGTTAACCGATAAAATCACCCATCTCGATGACGAAATGATGGAGAAAGTGGATGAAGCCTT
GCAGGTAAGCTTAGGACTCATCGAATTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10623.95 Da        Isoelectric Point: 5.0203

>AT231187 WP_014990916.1 NZ_CP090556:1144346-1144633 [Actinobacillus suis]
MAVISSKEFNQRASAVLKIAETEPVYITKWGKVVSVLASYAHYQAQTKSQSLADAFSSTVPTAILSTEAEQQFEQTLQQI
RQQSKMNVPDLSEWE

Download         Length: 288 bp

>AT231187 NZ_CP126114:357035-357316 [Neobacillus novalis]
GTGGCTGAATCAGGCGCAACTACGGAAATCTTAGTAAAGTTACCGCAACATCTTTTAACTGAGTTAGATGGTTTTGTAAA
GCAAGAAAATGTAAACCGCAGTGAGTTTATCTACCAAGCAACAAAAATGTATTTACGCGAACGAAAAAAGAGACAAATTC
GCGAGTCGATGAGACGTGGTTACATGGAAATGGCGAAGATCAATCTTAGAATTGCATCAGAAGCATTCCTAGCAGAATAT
GAGGCAGAACACACAGTTGAACGTCTTGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0G9D3

Antitoxin

Source ID Structure
AlphaFold DB K0G3K1

References