231180

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2735593..2736070 Replicon chromosome
Accession NZ_CP090547
Organism Xylella fastidiosa subsp. sandyi strain OC8

Toxin (Protein)


Gene name pasB Uniprot ID Q87CA4
Locus tag LZ756_RS13025 Protein ID WP_011097988.1
Coordinates 2735593..2735859 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A7G7TPD2
Locus tag LZ756_RS13030 Protein ID WP_004091377.1
Coordinates 2735843..2736070 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ756_RS12990 (LZ756_12990) 2731026..2731658 + 633 WP_230577891.1 calcium-binding protein -
LZ756_RS12995 (LZ756_12995) 2732235..2732996 - 762 WP_042836340.1 Bax inhibitor-1/YccA family protein -
LZ756_RS13020 (LZ756_13020) 2734188..2735582 + 1395 WP_042836341.1 hypothetical protein -
LZ756_RS13025 (LZ756_13025) 2735593..2735859 - 267 WP_011097988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ756_RS13030 (LZ756_13030) 2735843..2736070 - 228 WP_004091377.1 DUF6290 family protein Antitoxin
LZ756_RS13035 (LZ756_13035) 2736181..2736723 + 543 WP_020852392.1 hypothetical protein -
LZ756_RS13040 (LZ756_13040) 2737044..2737433 - 390 WP_024749101.1 DUF596 domain-containing protein -
LZ756_RS13045 (LZ756_13045) 2737444..2737701 - 258 WP_230577837.1 hemagglutinin -
LZ756_RS13050 (LZ756_13050) 2738009..2738386 - 378 WP_020852395.1 DUF596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10163.79 Da        Isoelectric Point: 10.6086

>T231180 WP_011097988.1 NZ_CP090547:c2735859-2735593 [Xylella fastidiosa subsp. sandyi]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Download         Length: 267 bp

>T231180 NZ_CP090547:c2735859-2735593 [Xylella fastidiosa subsp. sandyi]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8615.63 Da        Isoelectric Point: 5.0958

>AT231180 WP_004091377.1 NZ_CP090547:c2736070-2735843 [Xylella fastidiosa subsp. sandyi]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Download         Length: 228 bp

>AT231180 NZ_CP090547:c2736070-2735843 [Xylella fastidiosa subsp. sandyi]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAACGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGATGTGAGGAAAACGCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HDH1

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7TPD2

References