Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2261236..2261847 Replicon chromosome
Accession NZ_CP090547
Organism Xylella fastidiosa subsp. sandyi strain OC8

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag LZ756_RS10985 Protein ID WP_024749166.1
Coordinates 2261236..2261535 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag LZ756_RS10990 Protein ID WP_004085003.1
Coordinates 2261539..2261847 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ756_RS10930 (LZ756_10930) 2256393..2256689 + 297 WP_004089252.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ756_RS10935 (LZ756_10935) 2256693..2256998 + 306 WP_004089254.1 putative addiction module antidote protein -
LZ756_RS10940 (LZ756_10940) 2257009..2257362 - 354 WP_020851652.1 hypothetical protein -
LZ756_RS10945 (LZ756_10945) 2257359..2258000 - 642 WP_234759331.1 Gp138 family membrane-puncturing spike protein -
LZ756_RS10950 (LZ756_10950) 2257997..2258827 - 831 WP_042836628.1 hypothetical protein -
LZ756_RS10955 (LZ756_10955) 2258824..2259141 - 318 WP_020851655.1 hypothetical protein -
LZ756_RS10960 (LZ756_10960) 2259141..2259911 - 771 WP_024749165.1 hypothetical protein -
LZ756_RS10965 (LZ756_10965) 2259969..2260295 + 327 WP_004091353.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ756_RS10970 (LZ756_10970) 2260292..2260573 + 282 WP_004091355.1 XRE family transcriptional regulator -
LZ756_RS10975 (LZ756_10975) 2260632..2260925 - 294 Protein_2156 hypothetical protein -
LZ756_RS10980 (LZ756_10980) 2260873..2261181 - 309 WP_234759414.1 hypothetical protein -
LZ756_RS10985 (LZ756_10985) 2261236..2261535 + 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ756_RS10990 (LZ756_10990) 2261539..2261847 + 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
LZ756_RS10995 (LZ756_10995) 2261921..2263810 - 1890 WP_042836631.1 hypothetical protein -
LZ756_RS11000 (LZ756_11000) 2263767..2263931 - 165 WP_162849007.1 hypothetical protein -
LZ756_RS11005 (LZ756_11005) 2263958..2264380 - 423 WP_020852390.1 putative phage tail assembly chaperone -
LZ756_RS11010 (LZ756_11010) 2264377..2264814 - 438 WP_004087249.1 DUF3277 family protein -
LZ756_RS11015 (LZ756_11015) 2264824..2264991 - 168 WP_230577903.1 DUF3383 family protein -
LZ756_RS11020 (LZ756_11020) 2265277..2266146 - 870 WP_020851662.1 RNA-guided endonuclease TnpB family protein -
LZ756_RS11025 (LZ756_11025) 2266125..2266433 - 309 WP_020851663.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2233047..2273605 40558
- flank IS/Tn - - 2266465..2266686 221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T231179 WP_024749166.1 NZ_CP090547:2261236-2261535 [Xylella fastidiosa subsp. sandyi]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T231179 NZ_CP126107:232323-232673 [Neobacillus sp. SuZ13]
TTGATAGTCAAACGTGGTGACGTTTATTTCGCGGACCTATCCCCAGTTGTTGGTTCTGAACAAGGCGGCGTCCGACCTGT
ACTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTGATTGTTGCAGCGATTACAGCTCAAATTCAAAAAG
CCAAGCTTCCTACTCATGTAGAAATTGATGCGAAGCGCTACGGATTTGAACGAGATTCGGTCATTCTGTTAGAGCAAATT
CGCACAATTGATAAGCAGCGGTTAACCGATAAAATCACCCATCTCGATGACGAAATGATGGAGAAAGTGGATGAAGCCTT
GCAGGTAAGCCTGGGTCTCATCGAATTTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT231179 WP_004085003.1 NZ_CP090547:2261539-2261847 [Xylella fastidiosa subsp. sandyi]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT231179 NZ_CP126107:232037-232318 [Neobacillus sp. SuZ13]
GTGTCTGAATCCGGCGCAACTACGGAAATCTTAGTGAAGTTACCGCAACATCTTTTAACTGAATTAGATGGTTTTGTGAA
ACAAGAGAATGTAAACCGCAGCGAGTTTATCTACCAGGCAACAAAAATGTATTTACGCGAACGTAAAAAGAGACAAATTC
GCGAGTCGATGAGACGTGGATACATGGAAATGGCTAAGATAAATCTAGGGATTGCATCAGAAGCATTTTTAGCAGAATAT
GAGGCAGAACACACAGTTGAACGTCTTGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References