Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1632325..1632866 Replicon chromosome
Accession NZ_CP090547
Organism Xylella fastidiosa subsp. sandyi strain OC8

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LZ756_RS07890 Protein ID WP_020853079.1
Coordinates 1632325..1632648 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LZ756_RS07895 Protein ID WP_024748714.1
Coordinates 1632645..1632866 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ756_RS07855 (LZ756_07855) 1627448..1628278 + 831 WP_080702484.1 site-specific integrase -
LZ756_RS07860 (LZ756_07860) 1628995..1629411 - 417 WP_230577769.1 DUF3693 domain-containing protein -
LZ756_RS07865 (LZ756_07865) 1629521..1629814 + 294 WP_024748833.1 hypothetical protein -
LZ756_RS07870 (LZ756_07870) 1629816..1630082 + 267 WP_080702485.1 hypothetical protein -
LZ756_RS07875 (LZ756_07875) 1630119..1630268 + 150 WP_234759310.1 hypothetical protein -
LZ756_RS07880 (LZ756_07880) 1630642..1631865 + 1224 WP_051604011.1 replication initiation factor domain-containing protein -
LZ756_RS07885 (LZ756_07885) 1631852..1632184 + 333 WP_020853080.1 hypothetical protein -
LZ756_RS07890 (LZ756_07890) 1632325..1632648 - 324 WP_020853079.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LZ756_RS07895 (LZ756_07895) 1632645..1632866 - 222 WP_024748714.1 antitoxin MazE family protein Antitoxin
LZ756_RS07900 (LZ756_07900) 1633188..1633646 - 459 WP_230577771.1 DUF3693 domain-containing protein -
LZ756_RS07905 (LZ756_07905) 1633703..1634005 + 303 WP_042836558.1 hypothetical protein -
LZ756_RS07910 (LZ756_07910) 1633998..1634264 + 267 WP_080702486.1 hypothetical protein -
LZ756_RS07915 (LZ756_07915) 1634301..1634450 + 150 WP_234759311.1 hypothetical protein -
LZ756_RS07920 (LZ756_07920) 1634948..1636171 + 1224 WP_234759312.1 replication initiation factor domain-containing protein -
LZ756_RS07925 (LZ756_07925) 1636158..1636490 + 333 WP_020853080.1 hypothetical protein -
LZ756_RS07930 (LZ756_07930) 1636631..1636954 - 324 WP_020853079.1 type II toxin-antitoxin system PemK/MazF family toxin -
LZ756_RS07935 (LZ756_07935) 1636951..1637172 - 222 WP_024748714.1 antitoxin MazE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1584072..1661736 77664


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-105)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11808.87 Da        Isoelectric Point: 7.9848

>T231174 WP_020853079.1 NZ_CP090547:c1632648-1632325 [Xylella fastidiosa subsp. sandyi]
MIQRGDLVAVSLQGDYGKPRPALIVQSDLLTELDSVVLCPVTSDLRNAIFRVTVEPTPANGLRTLSQVMVDKISTLPRNK
INEPFGRINDERMKAIERALLLIVGII

Download         Length: 324 bp

>T231174 NZ_CP126104:480003-480353 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8507.76 Da        Isoelectric Point: 10.3534

>AT231174 WP_024748714.1 NZ_CP090547:c1632866-1632645 [Xylella fastidiosa subsp. sandyi]
MTSIHRPDSKVVHHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRALKSEQAEADVLRFTEKAITYIEGWK

Download         Length: 222 bp

>AT231174 NZ_CP126104:479716-479997 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References