Detailed information of TA system TA231173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/COG3657-DUF971
• Location: 1523285..1523890
• Replicon: chromosome
• Accession: NZ_CP090547
• Organism: Xylella fastidiosa subsp. sandyi strain OC8

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: B2I5N3
• Locus tag: LZ756_RS07345
• Protein ID: WP_004089252.1
• Coordinates: 1523594..1523890 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LZ756_RS07340
• Protein ID: WP_004089254.1
• Coordinates: 1523285..1523590 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ756_RS07305 (LZ756_07305)	1519540..1519932	-	393	WP_020851658.1	type II toxin-antitoxin system VapC family toxin	-
LZ756_RS07310 (LZ756_07310)	1519941..1520213	-	273	WP_024748527.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
LZ756_RS07315 (LZ756_07315)	1520373..1521143	+	771	WP_020851656.1	hypothetical protein	-
LZ756_RS07320 (LZ756_07320)	1521143..1521460	+	318	WP_020851655.1	hypothetical protein	-
LZ756_RS07325 (LZ756_07325)	1521457..1522287	+	831	WP_020851654.1	hypothetical protein	-
LZ756_RS07330 (LZ756_07330)	1522370..1522924	+	555	WP_234759298.1	Gp138 family membrane-puncturing spike protein	-
LZ756_RS07335 (LZ756_07335)	1522921..1523274	+	354	WP_020851652.1	hypothetical protein	-
LZ756_RS07340 (LZ756_07340)	1523285..1523590	-	306	WP_004089254.1	putative addiction module antidote protein	Antitoxin
LZ756_RS07345 (LZ756_07345)	1523594..1523890	-	297	WP_004089252.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ756_RS07350 (LZ756_07350)	1523989..1525134	+	1146	WP_020851651.1	baseplate J/gp47 family protein	-
LZ756_RS07355 (LZ756_07355)	1525131..1525691	+	561	WP_020851650.1	DUF2612 domain-containing protein	-
LZ756_RS07360 (LZ756_07360)	1525695..1526858	+	1164	WP_020851649.1	tail fiber protein	-
LZ756_RS07365 (LZ756_07365)	1526997..1527443	-	447	WP_020851648.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1434171..1526858	92687

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (49-95)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10790.57 Da
• Isoelectric Point: 10.0509

>T231173 WP_004089252.1 NZ_CP090547:c1523890-1523594 [Xylella fastidiosa subsp. sandyi]
MVELIKTSTFDAWINSLRDRKAAARIQARLDRLALGNPGDVKPVGAGISEMRIDHGPGYRIYFMKHGAVLILLLCGGDKS
SQVRDIEQAKALAALWKD

Nucleotide

• Length: 297 bp

>T231173 NZ_CP126102:256823-257173 [Cytobacillus firmus]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCAGAACAAGGCGGCGTCCGTCCAGT
GCTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTGTTGCAGCAATCACAGCTCAGATTCAAAAAG
CAAAGCTGCCTACTCACGTTGAAATTGATGCGAAGCGTTATGGTTTTGAAAGGGATTCGGTCATCTTATTAGAACAGATT
CGTACAATTGATAAACAACGCTTAACCGATAAAATAACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCGT
GCAAATCAGCTTAGGCCTCATCGAATTTTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10983.37 Da
• Isoelectric Point: 5.0941

>AT231173 WP_004089254.1 NZ_CP090547:c1523590-1523285 [Xylella fastidiosa subsp. sandyi]
MNNETFSRYDTADYLKTEEDIAAYMEAVMEEGGRDNPAFIARALGAVARARNLSQLARDVGMSRQGLDKALSNDGNPSFS
TILKVAKALGLRMSFTPSSMS

Nucleotide

• Length: 306 bp

>AT231173 NZ_CP126102:256537-256818 [Cytobacillus firmus]
GTGTCTGAGTCCAGCACAACAACAGAGATAATGGTGAAATTACCGCAGCATCTTTTAACCGAGTTAGACGGATTTGCTAA
ACAGGAAAACGTTAACCGGAGCGAATTCATTTATCAAGCAACCAAAATGTATTTGCGTGAACGCAAAAAGAGACAAATTC
GCGAGTCCATGAGACGTGGTTACATGGAGATGGCGAAAATAAATTTGACGATTGCATCTGAAGCATTTCAAGCGGAATAC
GAGGCAGAACACACAGTTGAACGTCTAGTTAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: A0A060HBK9