Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 1056409..1057082 Replicon chromosome
Accession NZ_CP090547
Organism Xylella fastidiosa subsp. sandyi strain OC8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZ756_RS04825 Protein ID WP_020851658.1
Coordinates 1056409..1056801 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZ756_RS04830 Protein ID WP_024748527.1
Coordinates 1056810..1057082 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ756_RS04790 (LZ756_04790) 1051466..1051999 + 534 WP_020852388.1 hypothetical protein -
LZ756_RS04795 (LZ756_04795) 1052000..1053496 + 1497 WP_020852389.1 DUF3383 domain-containing protein -
LZ756_RS04800 (LZ756_04800) 1053506..1053943 + 438 WP_004087249.1 DUF3277 family protein -
LZ756_RS04805 (LZ756_04805) 1053940..1054362 + 423 WP_020851660.1 putative phage tail assembly chaperone -
LZ756_RS04810 (LZ756_04810) 1054389..1054553 + 165 WP_162849007.1 hypothetical protein -
LZ756_RS04815 (LZ756_04815) 1054612..1055025 + 414 WP_234759391.1 hypothetical protein -
LZ756_RS04820 (LZ756_04820) 1055004..1056398 + 1395 WP_234759393.1 hypothetical protein -
LZ756_RS04825 (LZ756_04825) 1056409..1056801 - 393 WP_020851658.1 type II toxin-antitoxin system VapC family toxin Toxin
LZ756_RS04830 (LZ756_04830) 1056810..1057082 - 273 WP_024748527.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LZ756_RS04835 (LZ756_04835) 1057242..1058012 + 771 WP_020851656.1 hypothetical protein -
LZ756_RS04840 (LZ756_04840) 1058012..1058329 + 318 WP_020851655.1 hypothetical protein -
LZ756_RS04845 (LZ756_04845) 1058326..1059156 + 831 WP_020851654.1 hypothetical protein -
LZ756_RS04850 (LZ756_04850) 1059153..1059794 + 642 WP_020851653.1 Gp138 family membrane-puncturing spike protein -
LZ756_RS04855 (LZ756_04855) 1059791..1060144 + 354 WP_020851652.1 hypothetical protein -
LZ756_RS04860 (LZ756_04860) 1060155..1060460 - 306 WP_004089254.1 putative addiction module antidote protein -
LZ756_RS04865 (LZ756_04865) 1060464..1060760 - 297 WP_004089252.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ756_RS04870 (LZ756_04870) 1060859..1062004 + 1146 WP_020851651.1 baseplate J/gp47 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilT 1021848..1322833 300985


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

SpoVT-AbrB domain

(16-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14247.51 Da        Isoelectric Point: 5.6881

>T231169 WP_020851658.1 NZ_CP090547:c1056801-1056409 [Xylella fastidiosa subsp. sandyi]
MLDTNIISDIIRNPFGAVACRIEHVGYPNICTSVIVAAELRYGCTKNGSVKLLSRVQDILKTLPILPLDIPVDTTYGSIR
AELEAAGQLIGANDLLIAAHAYVLGLTLVTDNTREFSRIRGLDVQNWLER

Download         Length: 393 bp

>T231169 NZ_CP126100:c1372184-1371438 [Bacillus halotolerans]
ATGCTTTTATTCTTTCAAATCATGGTCTGGTGCACTATGGCCGCTTTAGGCTTATACGTATACGCCACATGGCGGTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGAAAAACATGGTATTTGCTGTTTGTTTTGGGCGCCATGATATACTGGA
CATATGATCCCTCTTCCCTGTTCACAAACTGGGAACGGTATGTCATTGTCGCTGTCAGCTTTGCTTTAATTGACGCTTTT
ATCTTTTTGAGCGCTTATGTGAAAAAACTGGCCGGCAGTGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCGATCGGCTGAAAACATACCAATATCTATTGAAAAACGAACCGATTCATGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGAATTGATAAACTGCTGAAAACCTATGCTGATAAAATGAATTTGACGGCCAGCCTT
TGTCACTATTCGACACAGTCTGATAAAGACCGGTTAACCGAGCACATGGAGGATCCCGCTGACGTGCAAACGAGGCTGGA
TCGAAAGGATGTCTATTACGACCAGTATGGAAAAGTAGTGCTCATTCCCTTTACAATTGAGACACAGAGCTATGTCATCA
AACTGACGTCTGACAGCATTGTAACGGAATTTGATTATTTGCTATTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10396.87 Da        Isoelectric Point: 4.8782

>AT231169 WP_024748527.1 NZ_CP090547:c1057082-1056810 [Xylella fastidiosa subsp. sandyi]
MPISSPLSRTKEAKLFRNNRSQAVRIPVEFELSGDRVLIHREGSKLIIEPITRPTNIVELLHEWRRETPLGPEDQFPDID
DMPAQPEDIL

Download         Length: 273 bp

>AT231169 NZ_CP126100:c1371438-1371268 [Bacillus halotolerans]
ATGGAAAACGCGTTTCAAAACGGATGCCATCCGCGGGCAAAGAAACCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCACACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGATGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References