Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84083..85706 Replicon plasmid p2017028-250
Accession NZ_CP090546
Organism Salmonella enterica strain 2017028-SE

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag L0F57_RS25115 Protein ID WP_000088046.1
Coordinates 84381..85706 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag L0F57_RS25110 Protein ID WP_024136327.1
Coordinates 84083..84376 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F57_RS25085 (L0F57_25085) 79955..81196 + 1242 WP_001053338.1 VWA domain-containing protein -
L0F57_RS26065 81287..81418 + 132 WP_000374059.1 hypothetical protein -
L0F57_RS25090 (L0F57_25090) 81759..82040 - 282 WP_000077926.1 hypothetical protein -
L0F57_RS25095 (L0F57_25095) 82090..82281 - 192 WP_000398480.1 hypothetical protein -
L0F57_RS25100 (L0F57_25100) 82373..82714 - 342 WP_001151575.1 hypothetical protein -
L0F57_RS25105 (L0F57_25105) 83087..83479 + 393 WP_000341066.1 hypothetical protein -
L0F57_RS25110 (L0F57_25110) 84083..84376 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
L0F57_RS25115 (L0F57_25115) 84381..85706 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
L0F57_RS25120 (L0F57_25120) 85767..85973 + 207 WP_000134171.1 hypothetical protein -
L0F57_RS25125 (L0F57_25125) 86075..86485 + 411 WP_000985911.1 hypothetical protein -
L0F57_RS25130 (L0F57_25130) 86498..87313 + 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
L0F57_RS25135 (L0F57_25135) 87597..88294 + 698 WP_095033700.1 IS1-like element IS1B family transposase -
L0F57_RS25140 (L0F57_25140) 88338..89003 - 666 WP_000490638.1 hypothetical protein -
L0F57_RS25145 (L0F57_25145) 89061..89441 - 381 WP_001426317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / oqxA / oqxB / aac(6')-Ib-cr / ARR-3 / dfrA27 / aadA16 / qacE / sul1 / qnrB6 / mph(A) / aac(3)-IId / blaCTX-M-55 - 1..250700 250700
- flank IS/Tn - - 87917..88294 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T231167 WP_000088046.1 NZ_CP090546:84381-85706 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T231167 NZ_CP126099:2355510-2356247 [Bacillus wiedmannii]
GTGAGCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTGCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTCAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATTCAAAAAGCTTAAACGCATTTTTAGATTCATATGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTATTATCGTTCCGTTAGA
ACACATTGAGCAATTGAATGAGCAGAAGGCGGTGCAAGTAGAAAATGTCGGAATAATACCAGCAAAAATGGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT231167 WP_024136327.1 NZ_CP090546:84083-84376 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT231167 NZ_CP126099:2356360-2356485 [Bacillus wiedmannii]
ATGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTAAAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References