Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4461875..4462656 Replicon chromosome
Accession NZ_CP090545
Organism Salmonella enterica strain 2017028-SE

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag L0F57_RS22000 Protein ID WP_000626099.1
Coordinates 4461875..4462366 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag L0F57_RS22005 Protein ID WP_001110452.1
Coordinates 4462363..4462656 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F57_RS21965 (4457870) 4457870..4458445 + 576 WP_001188509.1 transcriptional regulator -
L0F57_RS21975 (4458716) 4458716..4458793 - 78 Protein_4305 helix-turn-helix domain-containing protein -
L0F57_RS21980 (4458884) 4458884..4459216 - 333 WP_001165471.1 MerR family transcriptional regulator -
L0F57_RS21985 (4459288) 4459288..4459665 + 378 WP_000916345.1 EthD family reductase -
L0F57_RS21990 (4460698) 4460698..4460772 + 75 Protein_4308 porin family protein -
L0F57_RS21995 (4460875) 4460875..4461627 + 753 WP_000842434.1 non-specific acid phosphatase -
L0F57_RS22000 (4461875) 4461875..4462366 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
L0F57_RS22005 (4462363) 4462363..4462656 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
L0F57_RS22010 (4462973) 4462973..4463194 + 222 WP_001576552.1 hypothetical protein -
L0F57_RS22015 (4463459) 4463459..4464334 + 876 WP_000921674.1 AraC family transcriptional regulator -
L0F57_RS22020 (4464331) 4464331..4464618 + 288 WP_001269916.1 transcriptional regulator RtsB -
L0F57_RS22025 (4464641) 4464641..4464856 + 216 WP_001595136.1 hypothetical protein -
L0F57_RS22030 (4464864) 4464864..4465133 + 270 WP_010989096.1 hypothetical protein -
L0F57_RS22035 (4465427) 4465427..4466332 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T231164 WP_000626099.1 NZ_CP090545:c4462366-4461875 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T231164 NZ_CP126097:c2178466-2178290 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTTCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAATCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT231164 WP_001110452.1 NZ_CP090545:c4462656-4462363 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT231164 NZ_CP126097:2178407-2178504 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGAAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCAA
TGACTCTATTATAACATA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References