Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4332770..4333286 Replicon chromosome
Accession NZ_CP090545
Organism Salmonella enterica strain 2017028-SE

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag L0F57_RS21330 Protein ID WP_000220578.1
Coordinates 4332770..4333054 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L0F57_RS21335 Protein ID WP_000212724.1
Coordinates 4333044..4333286 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F57_RS21315 (4327982) 4327982..4329634 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
L0F57_RS21320 (4330043) 4330043..4332181 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L0F57_RS21325 (4332302) 4332302..4332766 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L0F57_RS21330 (4332770) 4332770..4333054 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0F57_RS21335 (4333044) 4333044..4333286 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L0F57_RS21340 (4333364) 4333364..4335277 - 1914 WP_001212137.1 BglG family transcription antiterminator -
L0F57_RS21345 (4335294) 4335294..4336034 - 741 WP_000779263.1 KDGP aldolase family protein -
L0F57_RS21350 (4336031) 4336031..4337149 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L0F57_RS21355 (4337133) 4337133..4338266 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T231163 WP_000220578.1 NZ_CP090545:c4333054-4332770 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T231163 NZ_CP126097:c2178466-2178290 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTTCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAATCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT231163 WP_000212724.1 NZ_CP090545:c4333286-4333044 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT231163 NZ_CP126097:2178252-2178349 [Bacillus subtilis]
GAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAGCCG
CTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References