Detailed information of TA system TA231158

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3578489..3579109
• Replicon: chromosome
• Accession: NZ_CP090545
• Organism: Salmonella enterica strain 2017028-SE

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: L0F57_RS17740
• Protein ID: WP_001280991.1
• Coordinates: 3578891..3579109 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: L0F57_RS17735
• Protein ID: WP_000344807.1
• Coordinates: 3578489..3578863 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F57_RS17725 (3573628)	3573628..3574821	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
L0F57_RS17730 (3574844)	3574844..3577993	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
L0F57_RS17735 (3578489)	3578489..3578863	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
L0F57_RS17740 (3578891)	3578891..3579109	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
L0F57_RS17745 (3579288)	3579288..3579839	+	552	WP_001278792.1	maltose O-acetyltransferase	-
L0F57_RS17750 (3579956)	3579956..3580426	+	471	WP_000136181.1	YlaC family protein	-
L0F57_RS17755 (3580482)	3580482..3580622	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
L0F57_RS17760 (3580628)	3580628..3580888	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
L0F57_RS17765 (3581113)	3581113..3582663	+	1551	WP_000213139.1	EAL domain-containing protein	-
L0F57_RS17775 (3582894)	3582894..3583283	+	390	WP_000961285.1	MGMT family protein	-
L0F57_RS17780 (3583316)	3583316..3583885	-	570	WP_000779803.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T231158 WP_001280991.1 NZ_CP090545:3578891-3579109 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T231158 NZ_CP126094:c1317650-1316904 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGTGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT231158 WP_000344807.1 NZ_CP090545:3578489-3578863 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT231158 NZ_CP126094:c1316904-1316734 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0