Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 950847..951507 Replicon chromosome
Accession NZ_CP090545
Organism Salmonella enterica strain 2017028-SE

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag L0F57_RS04650 Protein ID WP_000244756.1
Coordinates 951094..951507 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L0F57_RS04645 Protein ID WP_000351186.1
Coordinates 950847..951113 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F57_RS04625 (946775) 946775..948208 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
L0F57_RS04630 (948367) 948367..948678 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L0F57_RS04635 (948842) 948842..949501 + 660 WP_000250289.1 hemolysin III family protein -
L0F57_RS04640 (949617) 949617..950597 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
L0F57_RS04645 (950847) 950847..951113 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L0F57_RS04650 (951094) 951094..951507 + 414 WP_000244756.1 protein YgfX Toxin
L0F57_RS04655 (951560) 951560..952081 - 522 WP_001055885.1 flavodoxin FldB -
L0F57_RS04660 (952194) 952194..953090 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L0F57_RS04665 (953114) 953114..953827 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L0F57_RS04670 (953833) 953833..955566 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T231146 WP_000244756.1 NZ_CP090545:951094-951507 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T231146 NZ_CP126084:c4092903-4092553 [Paenibacillus woosongensis]
TTGATTGTAAAGCGCGGCGACGTATTTTTTGCAGACCTTTCCCCTGTGGTCGGTTCTGAACAGGGCGGGGTAAGACCTGT
GCTTATCATCCAGAACGATATCGGCAATCGATTCAGCCCTACGGTAATCGTTGCTGCCATTACCGCTCAAATTCAAAAAG
CGAAGCTCCCGACTCACGTTGAGATTGAAGCGGCTACGCATGGATTTGACCGGGATTCCGTCATCTTGCTTGAACAGATA
CGAACGATTGACAAGCAAAGATTAACGGACAAAATTACCCACCTGGATGATGAGACGATGAAAAAGGTTAACGATTCGCT
GCTTATTAGTCTGGGATTAATCGATTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT231146 WP_000351186.1 NZ_CP090545:950847-951113 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT231146 NZ_CP126084:c4093188-4092907 [Paenibacillus woosongensis]
ATGGCCAATATGCAGAACACCAAAAGGATTATGATCAGCTTACCGGATCATCTGTTACAGGAAGTGGATGGAATCGTAGC
TATGGAGAACTCCAATCGTAGTGAGCTTATTAGGCAAGCCATGAAACTGTATTTGAACGAACGGAAGAAACGCTTCATCC
GGGAGTCTATGCAGCGCGGCTACATGGAAATGGCCAAAATTAACTTAACCATGGCCTCTGAAGCTTTCCACGCGGAGGAA
GATGCAGACAGCACTCTGGACCGCCTAGTTAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References