Detailed information of TA system TA023114

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1744160..1744658
• Replicon: chromosome
• Accession: NC_011312
• Organism: Aliivibrio salmonicida LFI1238

Toxin (Protein)

• Gene name: -
• Uniprot ID: B6EME2
• Locus tag: VSAL_RS08715
• Protein ID: WP_012550275.1
• Coordinates: 1744395..1744658 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: B6EME1
• Locus tag: VSAL_RS08710
• Protein ID: WP_012550274.1
• Coordinates: 1744160..1744405 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VSAL_RS08690	1740065..1741711	-	1647	WP_173362140.1	methyl-accepting chemotaxis protein	-
VSAL_RS08695	1741945..1742901	+	957	WP_012549047.1	IS30-like element ISVsa7 family transposase	-
VSAL_RS08700	1743096..1743371	+	276	WP_044583260.1	DUF1778 domain-containing protein	-
VSAL_RS08705	1743368..1743871	+	504	WP_012550273.1	GNAT family N-acetyltransferase	-
VSAL_RS08710	1744160..1744405	-	246	WP_012550274.1	hypothetical protein	Antitoxin
VSAL_RS08715	1744395..1744658	-	264	WP_012550275.1	BrnT family toxin	Toxin
VSAL_RS08720	1744838..1745956	-	1119	WP_012550276.1	hypothetical protein	-
VSAL_RS08725	1745949..1746257	-	309	WP_012550277.1	hypothetical protein	-
VSAL_RS08730	1746239..1746901	-	663	WP_012550278.1	hypothetical protein	-
VSAL_RS08735	1747082..1747396	-	315	WP_012550279.1	type II toxin-antitoxin system MqsA family antitoxin	-
VSAL_RS08740	1747383..1747715	-	333	WP_023603298.1	type II toxin-antitoxin system RelE/ParE family toxin	-
VSAL_RS08745	1747924..1748373	-	450	WP_044583261.1	hypothetical protein	-
VSAL_RS08750	1748538..1748993	-	456	WP_012550282.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10100.47 Da
• Isoelectric Point: 6.7246

>T23114 WP_012550275.1 NC_011312:c1744658-1744395 [Aliivibrio salmonicida LFI1238]
MVNFEFDEVKSSSNLEKHGVDFNVAQLLWNDPDLIEIPVNTHDEPRYVVIAMLNGKHWTGVITYRGQNIRIISVRRSRKG
EVKVYES

Nucleotide

• Length: 264 bp

>T23114 NC_011312:c1744658-1744395 [Aliivibrio salmonicida LFI1238]
ATGGTTAATTTTGAATTTGATGAAGTTAAGAGTAGCTCGAATCTTGAAAAACATGGTGTGGATTTCAATGTAGCTCAATT
GCTTTGGAATGACCCAGATTTAATCGAGATCCCAGTAAATACTCACGATGAACCAAGATATGTCGTAATCGCAATGCTTA
ATGGTAAACATTGGACAGGCGTTATTACATATCGAGGTCAAAATATCCGAATAATTTCTGTTCGACGCTCAAGAAAAGGT
GAGGTAAAGGTTTATGAAAGCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9244.40 Da
• Isoelectric Point: 5.6845

>AT23114 WP_012550274.1 NC_011312:c1744405-1744160 [Aliivibrio salmonicida LFI1238]
MKANEFDAKFDDGDDILGDLDLSKSKRPMQSQKRVNVDFPTWMIESLDREANRIGVTRQSIIKVWLAERLESVAANHTAS
H

Nucleotide

• Length: 246 bp

>AT23114 NC_011312:c1744405-1744160 [Aliivibrio salmonicida LFI1238]
ATGAAAGCTAATGAATTTGATGCAAAATTTGACGATGGCGACGATATTCTAGGCGATTTAGATTTATCTAAATCTAAGCG
TCCAATGCAAAGTCAAAAACGAGTAAATGTTGATTTTCCAACATGGATGATCGAATCATTAGATCGTGAAGCGAATCGTA
TAGGTGTAACTCGCCAATCGATTATTAAAGTTTGGTTAGCGGAAAGGTTAGAAAGTGTAGCGGCGAATCACACAGCAAGT
CACTGA

Structures

Toxin

• AlphaFold DB: B6EME2

Antitoxin

• AlphaFold DB: B6EME1