Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4445973..4446754 | Replicon | chromosome |
| Accession | NZ_CP090541 | ||
| Organism | Salmonella enterica strain 2010112-SE | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | L0F62_RS21875 | Protein ID | WP_000626099.1 |
| Coordinates | 4445973..4446464 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | L0F62_RS21880 | Protein ID | WP_001110452.1 |
| Coordinates | 4446461..4446754 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0F62_RS21835 (4441159) | 4441159..4441401 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| L0F62_RS21840 (4441398) | 4441398..4441754 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| L0F62_RS21845 (4441751) | 4441751..4442623 | - | 873 | WP_033567082.1 | ParA family protein | - |
| L0F62_RS21850 (4442814) | 4442814..4442891 | - | 78 | Protein_4275 | helix-turn-helix domain-containing protein | - |
| L0F62_RS21855 (4442982) | 4442982..4443314 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| L0F62_RS21860 (4443386) | 4443386..4443763 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| L0F62_RS21865 (4444796) | 4444796..4444870 | + | 75 | Protein_4278 | porin family protein | - |
| L0F62_RS21870 (4444973) | 4444973..4445725 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| L0F62_RS21875 (4445973) | 4445973..4446464 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| L0F62_RS21880 (4446461) | 4446461..4446754 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| L0F62_RS21885 (4447071) | 4447071..4447292 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| L0F62_RS21890 (4447557) | 4447557..4448432 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| L0F62_RS21895 (4448429) | 4448429..4448716 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| L0F62_RS21900 (4448739) | 4448739..4448954 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| L0F62_RS21905 (4448962) | 4448962..4449231 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| L0F62_RS21910 (4449525) | 4449525..4450430 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T231139 WP_000626099.1 NZ_CP090541:c4446464-4445973 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T231139 NZ_CP126079:1505281-1505631 [Paenibacillus polymyxa]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTTAGCCCTACCGTGATCGTAGCAGCCATCACAGCACAGATTCAGAAGG
CAAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTGGAGCAAATC
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTGGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAGATCAGTCTCGGTTTGATTGATTTTTAG
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTTAGCCCTACCGTGATCGTAGCAGCCATCACAGCACAGATTCAGAAGG
CAAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTGGAGCAAATC
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTGGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAGATCAGTCTCGGTTTGATTGATTTTTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT231139 WP_001110452.1 NZ_CP090541:c4446754-4446461 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT231139 NZ_CP126079:1504993-1505274 [Paenibacillus polymyxa]
TTGGCCAATTTGCAGAACACCAAAAGAATAATGATCAGTTTGCCAGATCATCTCTTGCAGGAAGTGGACGGGATCGTAGC
TATGGAGAATTCCAACCGCAGTGAATTTATCAGGCAGGCAATGAAGCTTTATGTAGGTGAACGTAAAAAACGTTACATTC
GTGAAGCTATGCAGCGTGGATACATGGAAATGGCTAAAATTAACCTGACCATGGCATCTGAAGCCTTTCACGCGGAGGAA
GATGCAAACAGCACCTTGGGCCGTACAGTTAGCGGGGTGTAA
TTGGCCAATTTGCAGAACACCAAAAGAATAATGATCAGTTTGCCAGATCATCTCTTGCAGGAAGTGGACGGGATCGTAGC
TATGGAGAATTCCAACCGCAGTGAATTTATCAGGCAGGCAATGAAGCTTTATGTAGGTGAACGTAAAAAACGTTACATTC
GTGAAGCTATGCAGCGTGGATACATGGAAATGGCTAAAATTAACCTGACCATGGCATCTGAAGCCTTTCACGCGGAGGAA
GATGCAAACAGCACCTTGGGCCGTACAGTTAGCGGGGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|