Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4445973..4446754 Replicon chromosome
Accession NZ_CP090541
Organism Salmonella enterica strain 2010112-SE

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag L0F62_RS21875 Protein ID WP_000626099.1
Coordinates 4445973..4446464 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag L0F62_RS21880 Protein ID WP_001110452.1
Coordinates 4446461..4446754 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F62_RS21835 (4441159) 4441159..4441401 - 243 WP_197603740.1 hypothetical protein -
L0F62_RS21840 (4441398) 4441398..4441754 - 357 WP_033567083.1 hypothetical protein -
L0F62_RS21845 (4441751) 4441751..4442623 - 873 WP_033567082.1 ParA family protein -
L0F62_RS21850 (4442814) 4442814..4442891 - 78 Protein_4275 helix-turn-helix domain-containing protein -
L0F62_RS21855 (4442982) 4442982..4443314 - 333 WP_001165471.1 MerR family transcriptional regulator -
L0F62_RS21860 (4443386) 4443386..4443763 + 378 WP_000916345.1 EthD family reductase -
L0F62_RS21865 (4444796) 4444796..4444870 + 75 Protein_4278 porin family protein -
L0F62_RS21870 (4444973) 4444973..4445725 + 753 WP_000842434.1 non-specific acid phosphatase -
L0F62_RS21875 (4445973) 4445973..4446464 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
L0F62_RS21880 (4446461) 4446461..4446754 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
L0F62_RS21885 (4447071) 4447071..4447292 + 222 WP_001576552.1 hypothetical protein -
L0F62_RS21890 (4447557) 4447557..4448432 + 876 WP_000921674.1 AraC family transcriptional regulator -
L0F62_RS21895 (4448429) 4448429..4448716 + 288 WP_001269916.1 transcriptional regulator RtsB -
L0F62_RS21900 (4448739) 4448739..4448954 + 216 WP_001595136.1 hypothetical protein -
L0F62_RS21905 (4448962) 4448962..4449231 + 270 WP_010989096.1 hypothetical protein -
L0F62_RS21910 (4449525) 4449525..4450430 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T231139 WP_000626099.1 NZ_CP090541:c4446464-4445973 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T231139 NZ_CP126079:1505281-1505631 [Paenibacillus polymyxa]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTTAGCCCTACCGTGATCGTAGCAGCCATCACAGCACAGATTCAGAAGG
CAAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTGGAGCAAATC
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTGGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAGATCAGTCTCGGTTTGATTGATTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT231139 WP_001110452.1 NZ_CP090541:c4446754-4446461 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT231139 NZ_CP126079:1504993-1505274 [Paenibacillus polymyxa]
TTGGCCAATTTGCAGAACACCAAAAGAATAATGATCAGTTTGCCAGATCATCTCTTGCAGGAAGTGGACGGGATCGTAGC
TATGGAGAATTCCAACCGCAGTGAATTTATCAGGCAGGCAATGAAGCTTTATGTAGGTGAACGTAAAAAACGTTACATTC
GTGAAGCTATGCAGCGTGGATACATGGAAATGGCTAAAATTAACCTGACCATGGCATCTGAAGCCTTTCACGCGGAGGAA
GATGCAAACAGCACCTTGGGCCGTACAGTTAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References