231138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4235896..4236412 Replicon chromosome
Accession NZ_CP090541
Organism Salmonella enterica strain 2010112-SE

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag L0F62_RS20770 Protein ID WP_000220578.1
Coordinates 4235896..4236180 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L0F62_RS20775 Protein ID WP_000212724.1
Coordinates 4236170..4236412 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F62_RS20755 (4231108) 4231108..4232760 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
L0F62_RS20760 (4233169) 4233169..4235307 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L0F62_RS20765 (4235428) 4235428..4235892 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L0F62_RS20770 (4235896) 4235896..4236180 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0F62_RS20775 (4236170) 4236170..4236412 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L0F62_RS20780 (4236490) 4236490..4238403 - 1914 WP_001212137.1 BglG family transcription antiterminator -
L0F62_RS20785 (4238420) 4238420..4239160 - 741 WP_000779263.1 KDGP aldolase family protein -
L0F62_RS20790 (4239157) 4239157..4240275 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L0F62_RS20795 (4240259) 4240259..4241392 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T231138 WP_000220578.1 NZ_CP090541:c4236180-4235896 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T231138 NZ_CP126078:541452-541802 [Brevibacillus agri]
GTGATTGTCAAACGTGGCGATGTATTTTTCGCGGACCTGTCACCGGTCGTTGGCTCTGAGCAAGGAGGCGTGCGGCCTGT
TTTAGTCATTCAGAACGACATTGGAAATCGATTTAGTCCGACGGTCATCGTCGCCGCCATTACGGCCCAAATTCAGAAGG
CAAAACTGCCTACGCATGTGGAAATTGACGCAAAAACATATGGATTTGATCGTGACTCCGTCATTTTGTTGGAACAAATA
CGAACCATTGACAAACAGAGGCTGACTGATAAGATTACCCATCTTGACGACGAGATGATGGATCGGGTCAATGAGTCTTT
GCAAATCAGCTTGGGACTCATTGATTTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT231138 WP_000212724.1 NZ_CP090541:c4236412-4236170 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT231138 NZ_CP126078:541149-541448 [Brevibacillus agri]
ATGGTTGGAGGTGGATTTGTCTTGTCGAAGTCAAACACGAAACGCATCATGATCAGTTTGCCGCAACACTTGCTACAAGA
AGTGGATGGCGTCATTCAAAAGGAGAAATCCAATCGCAGCGAGTTCATTCGCCAGGCGATGCATTTGTATTTGAAGGAGC
GTAAAAAACGTACGATCCGCGAGACAATGCAAAAAGGGTATATGGAGATGGCGAAGATTAATCTGAAAATGGCATCGGAG
GCTTTTGGCGCTGAAGAAGAGGCTGACCATACTCTTGTCCGCTTAGTTAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References