Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4141635..4142211 Replicon chromosome
Accession NZ_CP090541
Organism Salmonella enterica strain 2010112-SE

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag L0F62_RS20375 Protein ID WP_001131963.1
Coordinates 4141924..4142211 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag L0F62_RS20370 Protein ID WP_000063142.1
Coordinates 4141635..4141937 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F62_RS20355 (4138145) 4138145..4140295 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
L0F62_RS20360 (4140390) 4140390..4140593 + 204 WP_000460616.1 YbdD/YjiX family protein -
L0F62_RS20365 (4140604) 4140604..4141560 + 957 WP_000187839.1 GTPase -
L0F62_RS20370 (4141635) 4141635..4141937 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
L0F62_RS20375 (4141924) 4141924..4142211 - 288 WP_001131963.1 BrnT family toxin Toxin
L0F62_RS20380 (4142480) 4142480..4143394 - 915 WP_000290512.1 restriction endonuclease -
L0F62_RS20385 (4143592) 4143592..4147101 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T231137 WP_001131963.1 NZ_CP090541:c4142211-4141924 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T231137 NZ_CP126077:c2730221-2729862 [Virgibacillus halodenitrificans]
TTGATCGTTCAAAGAGGTGAAGTATATTTCGCCGACTTATCCCCTGTGGTTGGATCGGAGCAGGGAGGCGTGCGCCCGGT
ATTGATCCTTCAAAATGATATAGGTAATCGGTTTAGCCCCACCGTTATTGTGGCAGCTATTACTGCGCAAATTCAAAAGG
CTAAGTTACCTACTCATGTTGAAATTAATGCAAAACGCTACGGATTCGACCGGAATTCTGTTATTCTGCTGGAACAAATC
CGTACATTGGATAAACAGAGATTAACAGATAAAATAACTAAACTTGATGCTGAAATGATGAATAAAATAAATCAGGCTCT
GGAAATTAGTCTGGGGCTGAAAGATATGTATGACCATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT231137 WP_000063142.1 NZ_CP090541:c4141937-4141635 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT231137 NZ_CP126077:c2730510-2730226 [Virgibacillus halodenitrificans]
TTGTCAGAGAGCTTACAGGAGATCTTAGTGAAAATACCAAAAAACCTATTGAATGAGGTGGATGGATTAATGAGATATGA
AAATAGTGACTTAAGTGATTTCATTTGTCAGGCTACAAGAAGCTACTTGCAGCATAAAAAAGATGAACATATCCAACAAT
TCCGTGAGACAATGCAAAAAGGCTATGAAGAAATGGGTCGCATTAATCTAACAATTGCTTCGGAAGCTTTTCAAGCTGAA
GAGGAGGCTGAAAACACCTTAGAGCGCTCTGTGATCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References