Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3499108..3499728 Replicon chromosome
Accession NZ_CP090541
Organism Salmonella enterica strain 2010112-SE

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L0F62_RS17275 Protein ID WP_001280991.1
Coordinates 3499510..3499728 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L0F62_RS17270 Protein ID WP_000344807.1
Coordinates 3499108..3499482 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F62_RS17260 (3494247) 3494247..3495440 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L0F62_RS17265 (3495463) 3495463..3498612 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L0F62_RS17270 (3499108) 3499108..3499482 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L0F62_RS17275 (3499510) 3499510..3499728 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L0F62_RS17280 (3499907) 3499907..3500458 + 552 WP_001278792.1 maltose O-acetyltransferase -
L0F62_RS17285 (3500575) 3500575..3501045 + 471 WP_000136181.1 YlaC family protein -
L0F62_RS17290 (3501101) 3501101..3501241 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L0F62_RS17295 (3501247) 3501247..3501507 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
L0F62_RS17300 (3501732) 3501732..3503282 + 1551 WP_000213139.1 EAL domain-containing protein -
L0F62_RS17310 (3503513) 3503513..3503902 + 390 WP_000961285.1 MGMT family protein -
L0F62_RS17315 (3503935) 3503935..3504504 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T231133 WP_001280991.1 NZ_CP090541:3499510-3499728 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T231133 NZ_CP126058:c5024925-5024557 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT231133 WP_000344807.1 NZ_CP090541:3499108-3499482 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT231133 NZ_CP126058:c5025143-5024922 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References